Carlo Cervellati

TL;DR: The possible link between PON1 with AD pathogenesis is discussed, eventual mechanistic pathways that could account from epidemiological observations are hypothesized and the methodological issue limitation in Pon1 studies is highlighted.

TL;DR: It is suggested that many of the changes observed in mitochondria could represent compensatory mechanisms by which ASD cells try to adapt to altered energy demand, possibly resulting from a chronic oxinflammatory status.

TL;DR: At least five of the compounds showing a significant selectivity for the parasite enzyme represent leads for trypanocidal drugs against this recently validated target.

TL;DR: The findings show that abnormalities of humoral and cell-mediated immunity together with chronic low-grade inflammation in multiple organs represent not only clinical manifestations of RTT but rather can contribute to its development and deteriorating course.

TL;DR: Investigation of changes in protein expression occurring in two cell lines under conditions leading to growth as adherent monolayers or to formation of multicellular tumor spheroids (MCTS) suggests that significant metabolic rearrangements occur during the conversion of cholangiocarcinomas cells to the MCTS phenotype.