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Carlos Henrique Tomich de Paula da Silva
Researcher at University of São Paulo
Publications - 153
Citations - 2998
Carlos Henrique Tomich de Paula da Silva is an academic researcher from University of São Paulo. The author has contributed to research in topics: Virtual screening & Pharmacophore. The author has an hindex of 24, co-authored 143 publications receiving 2420 citations. Previous affiliations of Carlos Henrique Tomich de Paula da Silva include Federal Rural University of Amazonia & Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto.
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Interaction of bovine (BSA) and human (HSA) serum albumins with ionic surfactants: spectroscopy and modelling.
TL;DR: The models for BSA and HSA with bound SDS suggest that the surfactant could be bound at the same sites as those reported in the crystal structure for the fatty acid, suggesting that the mechanism of the interaction is the same.
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Alzheimer's disease: A review from the pathophysiology to diagnosis, new perspectives for pharmacological treatment.
Leide Caroline dos Santos Picanço,Priscilla Farias Ozela,Maiara de Fátima de Brito Brito,Abraão Alves Pinheiro,Elias Carvalho Padilha,Francinaldo Sarges Braga,Carlos Henrique Tomich de Paula da Silva,Cleydson B. R. Santos,Joaquín María Campos Rosa,Lorane Izabel da Silva Hage-Melim +9 more
TL;DR: The present study aims to conduct a review of the epidemiology, pathophysiology, symptoms, diagnosis and treatment of Alzheimer's disease, emphasizing the research and development of new therapeutic approaches.
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Inhibition of horseradish peroxidase catalytic activity by new 3-phenylcoumarin derivatives: synthesis and structure-activity relationships.
Luciana M. Kabeya,Anderson A. de Marchi,Alexandre Kanashiro,Norberto Peporine Lopes,Carlos Henrique Tomich de Paula da Silva,Mônica Tallarico Pupo,Yara Maria Lucisano-Valim +6 more
TL;DR: Molecular modeling studies by docking suggested that interactions between the heme group in the HRP active site and the catechol group linked to the flavonoid B-ring or to the 3-phenyl coumarin ring are important to inhibit enzyme catalytic activity.
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Current topics in computer‐aided drug design
TL;DR: The addition of computer-aided drug design (CADD) technologies to the research and drug discovery approaches could lead to a reduction of up to 50% in the cost of drug design.
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Parkinson's Disease: A Review from Pathophysiology to Treatment.
Bianca L. B. Marino,Lucilene R. de Souza,Kessia P. A. Sousa,Jaderson Vieira Ferreira,Elias Carvalho Padilha,Carlos Henrique Tomich de Paula da Silva,Carlton A. Taft,Lorane Izabel da Silva Hage-Melim +7 more
TL;DR: Information is reviewed on the pathophysiology, symptomatology as well as the most current and relevant treatments of PD patients, which basically aims to control the symptoms, enabling better functional mobility and increasing life expectancy of the treated PD patients.