C
Carlos J. Sanchez
Researcher at United States Department of the Army
Publications - 31
Citations - 1977
Carlos J. Sanchez is an academic researcher from United States Department of the Army. The author has contributed to research in topics: Biofilm & Bacterial adhesin. The author has an hindex of 21, co-authored 31 publications receiving 1709 citations. Previous affiliations of Carlos J. Sanchez include University of Texas at San Antonio & University of Texas Health Science Center at San Antonio.
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Journal ArticleDOI
Biofilm formation by clinical isolates and the implications in chronic infections
Carlos J. Sanchez,Katrin Mende,Katrin Mende,Miriam L. Beckius,Kevin S. Akers,Kevin S. Akers,Desiree R Romano,Joseph C. Wenke,Clinton K. Murray +8 more
TL;DR: In patients with relapsing infections, the majority of serial isolates recovered from these individuals were observed to be strong biofilm producers in vitro, and strains from patients with persistent infections are positive for biofilm formation.
Journal ArticleDOI
The Pneumococcal Serine-Rich Repeat Protein Is an Intra-Species Bacterial Adhesin That Promotes Bacterial Aggregation In Vivo and in Biofilms
Carlos J. Sanchez,Pooja Shivshankar,Kim Stol,Samuel Trakhtenbroit,Paul M. Sullam,Karin Sauer,Peter W. M. Hermans,Carlos J. Orihuela +7 more
TL;DR: The first report to show the presence of biofilm-like structures in the lungs of animals infected with S. pneumoniae is reported and recombinant Non-repeat domains of SRRPs may be useful as vaccine antigens to protect against Gram-positive bacteria that cause infection.
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The Streptococcus pneumoniae adhesin PsrP binds to Keratin 10 on lung cells.
TL;DR: It is concluded that the BR domain of PsrP binds to K10 in a lectin‐independent manner, that K10 is expressed on lung cells and that vaccination with rPsrPBR is protective against pneumococcal disease.
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Streptococcus pneumoniae in Biofilms Are Unable to Cause Invasive Disease Due to Altered Virulence Determinant Production
Carlos J. Sanchez,Nikhil Kumar,Anel Lizcano,Pooja Shivshankar,Julie C. Dunning Hotopp,James H. Jorgensen,Hervé Tettelin,Carlos J. Orihuela +7 more
TL;DR: It is suggested that biofilms do not directly contribute to development of IPD and may instead confer a quiescent mode of growth during colonization.
Journal ArticleDOI
Streptococcus pneumoniae Biofilm Formation Is Strain Dependent, Multifactorial, and Associated with Reduced Invasiveness and Immunoreactivity during Colonization
Krystle Blanchette-Cain,Cecilia A. Hinojosa,Ramya Akula Suresh Babu,Anel Lizcano,Norberto Gonzalez-Juarbe,Carmen Muñoz-Almagro,Carlos J. Sanchez,Molly A. Bergman,Carlos J. Orihuela +8 more
TL;DR: The first temporal characterization of Streptococcus pneumoniae biofilm formation in vivo is demonstrated and it is suggested that biofilms form during colonization and suggest that they may contribute to persistence through a hyperadhesive, noninvasive state that elicits a dampened cytokine response.