Carlos López-Otín

TL;DR: In this paper, a regulatory pathway involving miR-29 and p53 tumour suppressor was described for progeria development in mice, and it was shown that pharmacological restoration of the somatotroph axis in these mice delayed the onset of their progeroid features, significantly extending their lifespan and supporting the importance of systemic alterations in progeria progression.

TL;DR: 1,25-dihydroxyvitamin D3 is proposed as an important regulator of the expression of the apoD gene in breast carcinomas and may be of interest as a biochemical marker of the action of these compounds as inhibitors of breast cancer cell growth or as chemotherapeutic agents in the prevention of breast cancers.

TL;DR: It is speculated that autophagy might constitute an actionable therapeutic target to treat progeroid syndromes because it extends lifespan in Saccharomyces cerevisiae in an Atg5- and Atg7-dependent fashion, supporting the notion that methionine restriction may indeed mediate its antiaging effects through the induction of macroautophagy/autophagic flux.

TL;DR: Results suggest that luteolin could be employed as a prototypic modifying disease-agent to create new chondroprotective compounds aimed to specifically block the unwanted aggrecanase activities in arthritic diseases.