C
Carlos López-Otín
Researcher at University of Oviedo
Publications - 521
Citations - 99434
Carlos López-Otín is an academic researcher from University of Oviedo. The author has contributed to research in topics: Matrix metalloproteinase & Gene. The author has an hindex of 126, co-authored 494 publications receiving 83933 citations. Previous affiliations of Carlos López-Otín include University of Barcelona & Lund University.
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Journal ArticleDOI
Gly-Gly-X, a novel consensus sequence for the proteolytic processing of viral and cellular proteins.
TL;DR: The sequence Gly-Gly-X together with other physical properties of the protein seems to be a recognition sequence for the processing of a variety of viral and cellular proteins.
Journal ArticleDOI
The anti-metastatic activity of collagenase-2 in breast cancer cells is mediated by a signaling pathway involving decorin and miR-21.
Clara Soria-Valles,Ana Gutiérrez-Fernández,Marc Guiu,Bernard Mari,Antonio Fueyo,Roger R. Gomis,Carlos López-Otín +6 more
TL;DR: It is shown that Mmp8 expression causes a decrease in miR-21 levels that in turn leads to a reduction in tumor growth and lung metastasis formation by MDA-MB-231 breast cancer cells overexpressing this metalloproteinase.
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Collagenase-2 Deficiency or Inhibition Impairs Experimental Autoimmune Encephalomyelitis in Mice
Alicia R. Folgueras,Antonio Fueyo,Olivia García-Suárez,Jennifer H. Cox,Aurora Astudillo,Paolo Tortorella,Cristina Campestre,Ana Gutiérrez-Fernández,Miriam Fanjul-Fernández,Caroline J. Pennington,Dylan R. Edwards,Christopher M. Overall,Carlos López-Otín +12 more
TL;DR: It is concluded that MMP-8 plays an important role in EAE development and it is proposed that this enzyme may be a novel therapeutic target in human neuro-inflammatory diseases such as multiple sclerosis.
Journal ArticleDOI
Proteomic Profiling of Adipose Tissue from Zmpste24−/− Mice, a Model of Lipodystrophy and Premature Aging, Reveals Major Changes in Mitochondrial Function and Vimentin Processing
Juan R. Peinado,Pedro M. Quirós,Marina R. Pulido,Guillermo Mariño,María L. Martínez-Chantar,Rafael Vázquez-Martínez,José M.P. Freije,Carlos López-Otín,María M. Malagón +8 more
TL;DR: The findings in Zmpste24−/− mice may be useful to unveil the mechanisms underlying adipose tissue dysfunction and its overall contribution to body homeostasis in progeria and other lipodystrophy syndromes as well as to develop novel strategies to prevent or ameliorate these diseases.
Journal ArticleDOI
CCND2 and CCND3 hijack immunoglobulin light-chain enhancers in cyclin D1 - mantle cell lymphoma.
David Martín-García,Alba Navarro,Rafael Valdés-Mas,Guillem Clot,Jesús Gutiérrez-Abril,Miriam Prieto,Inmaculada Ribera-Cortada,Renata Woroniecka,Grzegorz Rymkiewicz,Susanne Bens,Susanne Bens,Laurence de Leval,Andreas Rosenwald,Judith A. Ferry,Eric D. Hsi,Kai Fu,Jan Delabie,Jan Delabie,Dennis D. Weisenburger,Daphne de Jong,Fina Climent,Sheila J.M. O’Connor,Steven H. Swerdlow,David Torrents,David Torrents,Sergi Beltran,Blanca Espinet,Blanca Gonzalez-Farre,Luis Veloza,Dolors Costa,Estella Matutes,Reiner Siebert,Reiner Siebert,German Ott,Leticia Quintanilla-Martinez,Elaine S. Jaffe,Carlos López-Otín,Itziar Salaverria,Xose S. Puente,Elias Campo,Sílvia Beà +40 more
TL;DR: Virtually all cyclin D1- MCLs carry CCND2/CCND3 rearrangements with immunoglobulin genes, including a novel IGK/L enhancer hijacking mechanism.