C
Carmen Correale
Researcher at Humanitas University
Publications - 55
Citations - 1581
Carmen Correale is an academic researcher from Humanitas University. The author has contributed to research in topics: Inflammatory bowel disease & Inflammation. The author has an hindex of 21, co-authored 48 publications receiving 1282 citations.
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Journal ArticleDOI
VEGF-C–dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease
Silvia D'Alessio,Carmen Correale,Carlotta Tacconi,Alessandro Gandelli,Giovanni Pietrogrande,Stefania Vetrano,Marco Genua,Vincenzo Arena,Antonino Spinelli,Laurent Peyrin-Biroulet,Claudio Fiocchi,Silvio Danese +11 more
TL;DR: It is demonstrated that adenoviral induction of prolymphangiogenic factor VEGF-C provides marked protection against the development of acute and chronic colitis in 2 different animal models and suggested that correction of defective lymphatic function with VEGf-C has potential as a therapeutic strategy for IBD.
Journal ArticleDOI
The lymphatic system controls intestinal inflammation and inflammation-associated colon cancer through the chemokine decoy receptor D6
Stefania Vetrano,Elena Monica Borroni,Adelaida Sarukhan,Benedetta Savino,Raffaella Bonecchi,Carmen Correale,Vincenzo Arena,Massimo Fantini,Massimo Roncalli,Alberto Malesci,Alberto Mantovani,Massimo Locati,Silvio Danese +12 more
TL;DR: A new unexpected role for the lymphatic system in the pathogenesis of IBD and intestinal cancer, and candidate chemokines as novel players in tumour promotion and progression are revealed.
Journal ArticleDOI
Multiple pathogenic roles of microvasculature in inflammatory bowel disease: a Jack of all trades.
TL;DR: This review contemplates the newly uncovered contribution of intestinal microcirculation to pathogenesis and maintenance of chronic intestinal inflammation and assess the multiple roles of the microvascular endothelium in innate immunity, leukocyte recruitment, coagulation and perfusion, and immune-driven angiogenesis in IBD.
Journal ArticleDOI
Identification of serum and tissue micro-RNA expression profiles in different stages of inflammatory bowel disease
Marisa Iborra,Francesca Bernuzzi,Carmen Correale,Stefania Vetrano,Gionata Fiorino,Belén Beltrán,Francesco Marabita,Massimo Locati,Antonino Spinelli,Pilar Nos,Pietro Invernizzi,Silvio Danese +11 more
TL;DR: The results suggest the existence of specific miRNA expression patterns associated with IBD and their different stages and support the utility of miRNAs as possible biomarkers and needs to be validated in a large prospective cohort.
Journal ArticleDOI
Vascular Endothelial Growth Factor C Disrupts the Endothelial Lymphatic Barrier to Promote Colorectal Cancer Invasion
Carlotta Tacconi,Carmen Correale,Alessandro Gandelli,Antonino Spinelli,Elisabetta Dejana,Silvia D'Alessio,Silvio Danese +6 more
TL;DR: VEGFC signaling via VEGFR3 promotes lymphangiogenesis and metastasis by orthotopic colorectal tumors in mice and reduces lymphatic endothelial barrier integrity, and strategies to block VEGFC might be developed to prevent CRC metastasis in patients.