R
Raffaella Bonecchi
Researcher at Humanitas University
Publications - 99
Citations - 9168
Raffaella Bonecchi is an academic researcher from Humanitas University. The author has contributed to research in topics: Chemokine receptor & CCR1. The author has an hindex of 36, co-authored 94 publications receiving 8121 citations. Previous affiliations of Raffaella Bonecchi include Mario Negri Institute for Pharmacological Research & University of Brescia.
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Journal ArticleDOI
Differential Expression of Chemokine Receptors and Chemotactic Responsiveness of Type 1 T Helper Cells (Th1s) and Th2s
Raffaella Bonecchi,Giancarlo Bianchi,Paola Panina Bordignon,Daniele D’Ambrosio,Rosmarie Lang,Alessandro Borsatti,Silvano Sozzani,Paola Allavena,Patrick Gray,Alberto Mantovani,Francesco Sinigaglia +10 more
TL;DR: T helper cells type 1 (Th1s) that produce interferon-γ predominantly mediate cellular immune responses and are involved in the development of chronic inflammatory conditions, whereas Th2s which produce large amounts of IL-4 and IL-5 upregulate IgE production and are prominent in the pathogenesis of allergic diseases.
Journal Article
Differential regulation of chemokine receptors during dendritic cell maturation: a model for their trafficking properties.
Silvano Sozzani,Paola Allavena,Giovanna D'Amico,Walter Luini,Giancarlo Bianchi,Motoji Kataura,Toshio Imai,Osamu Yoshie,Raffaella Bonecchi,Alberto Mantovani +9 more
TL;DR: Concomitantly, the expression of CCR7 and the migration to its ligand EBI1 ligand chemokine (ELC)/macrophage inflammatory protein (MIP)-3beta, a chemokines expressed in lymphoid organs, were strongly up-regulated, though with slower kinetics (24-48 h).
Journal Article
Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells
Daniele D’Ambrosio,Andrea Iellem,Raffaella Bonecchi,D. Mazzeo,Silvano Sozzani,Alberto Mantovani,Francesco Sinigaglia +6 more
TL;DR: Analysis of polarized subsets of CD8+ T cells reveals a similar pattern of chemokine receptor expression and modulation of responsiveness, suggesting that an up-regulation of CCR4 and CCR8 following Ag encounter may contribute to the proper positioning of activated T cells within sites of antigenic challenge and/or specialized areas of lymphoid tissues.
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Tuning inflammation and immunity by chemokine sequestration: decoys and more
TL;DR: A set of chemokine receptors are structurally unable to elicit migration or conventional signalling responses after ligand engagement, and therefore represent a general strategy to tune, shape and temper innate and adaptive immunity.
Journal ArticleDOI
Neutrophil diversity and plasticity in tumour progression and therapy.
Sébastien Jaillon,Andrea Ponzetta,Diletta Di Mitri,Angela Santoni,Raffaella Bonecchi,Alberto Mantovani,Alberto Mantovani +6 more
TL;DR: The emerging dual role played by neutrophils in the tumour microenvironment is discussed, while also mediating antitumour immune responses, and it is suggested that neutrophil function could be manipulated in myeloid cell-based therapeutic approaches to improve patient outcomes.