C
Carmen Gomez-Guerrero
Researcher at Complutense University of Madrid
Publications - 97
Citations - 4567
Carmen Gomez-Guerrero is an academic researcher from Complutense University of Madrid. The author has contributed to research in topics: Inflammation & Proinflammatory cytokine. The author has an hindex of 38, co-authored 95 publications receiving 3876 citations. Previous affiliations of Carmen Gomez-Guerrero include Carlos III Health Institute & Hospital Clínico San Carlos.
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Journal ArticleDOI
Animal models of cardiovascular diseases
Carlos Zaragoza,Carmen Gomez-Guerrero,José Luis Martín-Ventura,Luis Miguel Blanco-Colio,Begoña Lavin,Beñat Mallavia,Carlos Tarin,Sebastian Mas,Alberto Ortiz,Jesús Egido +9 more
TL;DR: Models of atherothrombotic diseases, including expanding and occlusive animal models, as well as models of heart failure are described, which may help to find more efficient and reliable solutions against human cardiovascular diseases.
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Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation.
Leocadio Rodríguez-Mañas,Mariam El-Assar,Susana Vallejo,Pedro López-Dóriga,Joaquin Solís,Roberto Petidier,Manuel Montes,Julián Nevado,Marta Castro,Carmen Gomez-Guerrero,Concepción Peiró,Carlos F. Sánchez-Ferrer +11 more
TL;DR: It is concluded that the age‐dependent endothelial dysfunction in human vessels is due to the combined effect of oxidative stress and vascular wall inflammation.
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Suppressors of cytokine signaling abrogate diabetic nephropathy.
Guadalupe Ortiz-Muñoz,Virginia Lopez-Parra,Oscar Lopez-Franco,Paula Fernandez-Vizarra,Beñat Mallavia,Claudio Flores,Ana Belen Sanz,Julia Ramírez Blanco,Sergio Mezzano,Alberto Ortiz,Jesús Egido,Carmen Gomez-Guerrero +11 more
TL;DR: Results provide direct evidence for a link between the JAK/STAT/SOCS axis and hyperglycemia-induced cell responses in the kidney and suppressors of cytokine signaling by increasing intracellular SOCS proteins may have therapeutic potential in diabetic nephropathy.
Journal Article
Interaction of IgA with Fc alpha receptors of human mesangial cells activates transcription factor nuclear factor-kappa B and induces expression and synthesis of monocyte chemoattractant protein-1, IL-8, and IFN-inducible protein 10.
TL;DR: It is shown that stimulation of Fc alphaR in MC induces gene expression of MCP-1, IL-8, and IP-10, a process partially mediated by NF-kappa B activation, which may be of importance for a better understanding of the pathogenesis of glomerular damage in IgA immune complex-related diseases.
Journal Article
Soluble IgA and IgG aggregates are catabolized by cultured rat mesangial cells and induce production of TNF-alpha and IL-6, and proliferation
TL;DR: Results show that Fc alpha and Fc gamma receptor occupancy of MC induces the synthesis and release of inflammatory cytokines and proliferation, as well as the phagocytosis of stimulatory proteins.