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Carol A. Barnes
Researcher at University of Arizona
Publications - 277
Citations - 40601
Carol A. Barnes is an academic researcher from University of Arizona. The author has contributed to research in topics: Hippocampal formation & Hippocampus. The author has an hindex of 98, co-authored 272 publications receiving 37781 citations. Previous affiliations of Carol A. Barnes include University of Oslo & University of California, Davis.
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Region-specific age effects on AMPA sensitivity: electrophysiological evidence for loss of synaptic contacts in hippocampal field CA1.
TL;DR: The data do support the conclusion that there are fewer synapses per Schaffer collateral branch in old versus young CA1 pyramidal cells, and the pattern of results obtained in the present experiments supports the following conclusions.
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Pattern Separation Deficits May Contribute to Age-Associated Recognition Impairments
TL;DR: The current experiments suggest that alterations in the perirhinal cortex may be responsible for reducing aged animals' ability to distinguish new stimuli from ones that have been encountered previously, and support the view that age-related impairments in object recognition arise from old animals behaving as if novel objects are familiar.
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Impact of aging brain circuits on cognition.
Rachel D. Samson,Carol A. Barnes +1 more
TL;DR: There is remarkable consistency in the pattern of age‐related neural and cognitive change observed in healthy humans and other animals, including changes in cognitive operations that are known to be dependent on the hippocampus, as well as those requiring intact prefrontal cortical circuits.
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Memantine protects against LPS-induced neuroinflammation, restores behaviorally-induced gene expression and spatial learning in the rat.
Susanna Rosi,Almira Vazdarjanova,Víctor Ramírez-Amaya,Víctor Ramírez-Amaya,Paul F. Worley,Carol A. Barnes,Gary L. Wenk +6 more
TL;DR: The data indicate that memantine therapy at low doses, recreating plasma levels similar to those of therapeutic doses in human, acts in part through its ability to reduce the effects of neuroinflammation, resulting in normal gene expression patterns and spatial learning.
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Enhancement of hippocampal field potentials in rats exposed to a novel, complex environment
TL;DR: The hippocampus plays a crucial role in place learning in rodents and also exhibits a long-term enhancement of synaptic strength and postsynaptic excitability following electrical stimulation of its principal afferents, which may be related.