Carol A. Barnes

TL;DR: This review article presents a novel model for understanding, preventing, and treating age-related cognitive impairment (ARCI) based on concepts borrowed from precision medicine and concludes with a discussion of steps that must be taken to move the field forward.

TL;DR: An information‐theoretic approach that derives, from the role of the hippocampus in memory, constraints on its anatomical and physiological structure is discussed, and the observed structure is consistent with such constraints.

TL;DR: In this article, the authors provide a resource for longitudinal studies, using animal models, directed at understanding and modifying the relationship between cognition and brain structure and function throughout life, and propose that forthcoming longitudinal studies will build upon a wealth of knowledge gleaned from prior cross-sectional designs to identify early predictors of variability in cognitive function during aging, and characterize fundamental neurobiological mechanisms that underlie the vulnerability to, and the trajectory of cognitive decline.

TL;DR: A preclinical mouse model of CHF that exhibits both spatial memory and object recognition dysfunction is demonstrated and this CHF-induced cognitive impairment is attenuated by treatment with systemic Ang-(1–7).

TL;DR: 3,4-DAP was found to selectively improve memory performance of the old animals, and, within that age group, only improved performance on the short-term memory task, suggesting it may be effective for only a restricted set of age-related memory problems.