C
Carol A. Marchant
Researcher at University of Leeds
Publications - 13
Citations - 1757
Carol A. Marchant is an academic researcher from University of Leeds. The author has contributed to research in topics: Software system & Quantitative structure–activity relationship. The author has an hindex of 11, co-authored 13 publications receiving 1567 citations.
Papers
More filters
Journal ArticleDOI
Current status of methods for defining the applicability domain of (quantitative) structure-activity relationships. The report and recommendations of ECVAM Workshop 52.
Tatiana I. Netzeva,Andrew Worth,Tom Aldenberg,Romualdo Benigni,Mark T. D. Cronin,Paola Gramatica,Joanna Jaworska,Scott Kahn,Gilles Klopman,Carol A. Marchant,Glenn J. Myatt,Nina Nikolova-Jeliazkova,Grace Patlewicz,Roger Perkins,David W. Roberts,Terry W Schultz,David T. Stanton,Johannes J.M. van de Sandt,Weida Tong,Gilman Veith,Chihae Yang +20 more
TL;DR: This is the 52nd report of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM) to provide a source of input to the development of an OECD Guidance Document on (Q)SAR Validation.
Journal ArticleDOI
In Silico Tools for Sharing Data and Knowledge on Toxicity and Metabolism: Derek for Windows, Meteor, and Vitic
TL;DR: Derek for Windows and Meteor are knowledge-based expert systems that predict the toxicity and metabolism of a chemical, respectively and Vitic is a chemically intelligent toxicity database.
Journal ArticleDOI
Knowledge-Based Expert Systems for Toxicity and Metabolism Prediction: DEREK, StAR and METEOR
TL;DR: The number of correctly identified mutagens and the predictions compared to their Salmonella typhimurium mutagenicity data has increased and work on improving the predictive capabilities of DEREK, StAR and METEOR is in progress.
Journal ArticleDOI
Computer prediction of possible toxic action from chemical structure: an update on the DEREK system
J.E. Ridings,M.D. Barratt,R. Cary,C.G. Earnshaw,C.E. Eggington,M.K. Ellis,Philip N. Judson,J.J. Langowski,Carol A. Marchant,M.P. Payne,William P. Watson,T.D. Yih +11 more
TL;DR: Computer-based assessment of potential toxicity has become increasingly popular in recent years and DEREK's predictive capabilities for these toxicological end-points has been demonstrated and work is in progress to develop further DEREk's ability to report the reasoning behind its predictions.
Journal ArticleDOI
The expanding role of predictive toxicology: an update on the (Q)SAR models for mutagens and carcinogens.
Romualdo Benigni,Tatiana I. Netzeva,Emilio Benfenati,Cecilia Bossa,Rainer Franke,Christoph Helma,Etje Hulzebos,Carol A. Marchant,Ann M. Richard,Yin Tak Woo,Chihae Yang +10 more
TL;DR: Findings from the survey on (Q)SARs for mutagenicity and carcinogenicity are summarized, key aspects are discussed, and a broader view towards future needs and perspectives is given.