G
Grace Patlewicz
Researcher at United States Environmental Protection Agency
Publications - 175
Citations - 10053
Grace Patlewicz is an academic researcher from United States Environmental Protection Agency. The author has contributed to research in topics: Medicine & Computer science. The author has an hindex of 44, co-authored 151 publications receiving 8019 citations. Previous affiliations of Grace Patlewicz include University of Santiago de Compostela & DuPont.
Papers
More filters
Journal ArticleDOI
Mechanistic applicability domain classification of a local lymph node assay dataset for skin sensitization.
David W. Roberts,Grace Patlewicz,Petra S. Kern,Frank Gerberick,Ian Kimber,Rebecca J. Dearman,Cindy A. Ryan,David A. Basketter,Aynur O. Aptula +8 more
TL;DR: It is shown that assignment to a reaction mechanistic domain is a critical first step in a strategic approach to understanding, ultimately on a quantitative basis, how chemical properties influence the potency of skin sensitizing chemicals.
Journal ArticleDOI
Current status of methods for defining the applicability domain of (quantitative) structure-activity relationships. The report and recommendations of ECVAM Workshop 52.
Tatiana I. Netzeva,Andrew Worth,Tom Aldenberg,Romualdo Benigni,Mark T. D. Cronin,Paola Gramatica,Joanna Jaworska,Scott Kahn,Gilles Klopman,Carol A. Marchant,Glenn J. Myatt,Nina Nikolova-Jeliazkova,Grace Patlewicz,Roger Perkins,David W. Roberts,Terry W Schultz,David T. Stanton,Johannes J.M. van de Sandt,Weida Tong,Gilman Veith,Chihae Yang +20 more
TL;DR: This is the 52nd report of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM) to provide a source of input to the development of an OECD Guidance Document on (Q)SAR Validation.
Journal ArticleDOI
The CompTox Chemistry Dashboard: a community data resource for environmental chemistry
Antony J. Williams,Christopher M. Grulke,Jeff Edwards,Andrew D. McEachran,Kamel Mansouri,Kamel Mansouri,Kamel Mansouri,Nancy C. Baker,Grace Patlewicz,Imran Shah,John F. Wambaugh,Richard S. Judson,Ann M. Richard +12 more
TL;DR: The U.S. Environmental Protection Agency’s web-based CompTox Chemistry Dashboard is addressing needs by integrating diverse types of relevant domain data through a cheminformatics layer, built upon a database of curated substances linked to chemical structures.
Journal ArticleDOI
ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology
Ann M. Richard,Richard S. Judson,Keith A. Houck,Christopher M. Grulke,Patra Volarath,Inthirany Thillainadarajah,Chihae Yang,James F. Rathman,Matthew T. Martin,John F. Wambaugh,Thomas B. Knudsen,Jayaram Kancherla,Kamel Mansouri,Grace Patlewicz,Antony J. Williams,Stephen B. Little,Kevin M. Crofton,Russell S. Thomas +17 more
TL;DR: The ToxCast chemical library is demonstrated to provide comprehensive coverage of the knowledge domains and target inventories of potential interest to EPA, and the varied representations and approaches presented here define local chemistry domains potentially worthy of further investigation.
Journal ArticleDOI
Compilation of historical local lymph node data for evaluation of skin sensitization alternative methods
G. Frank Gerberick,Cindy A. Ryan,Petra S. Kern,Harald Schlatter,Rebecca J. Dearman,Ian Kimber,Grace Patlewicz,David A. Basketter +7 more
TL;DR: A database of robust in vivo data to calibrate, evaluate, and eventually validate new approaches for skin sensitization testing is provided, which represents both the chemical and biologic diversity that is known to exist for chemical allergens and non‐allergens.