D
David W. Roberts
Researcher at Liverpool John Moores University
Publications - 149
Citations - 7549
David W. Roberts is an academic researcher from Liverpool John Moores University. The author has contributed to research in topics: Local lymph node assay & European union. The author has an hindex of 40, co-authored 146 publications receiving 6556 citations.
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Journal ArticleDOI
Mechanistic applicability domain classification of a local lymph node assay dataset for skin sensitization.
David W. Roberts,Grace Patlewicz,Petra S. Kern,Frank Gerberick,Ian Kimber,Rebecca J. Dearman,Cindy A. Ryan,David A. Basketter,Aynur O. Aptula +8 more
TL;DR: It is shown that assignment to a reaction mechanistic domain is a critical first step in a strategic approach to understanding, ultimately on a quantitative basis, how chemical properties influence the potency of skin sensitizing chemicals.
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Current status of methods for defining the applicability domain of (quantitative) structure-activity relationships. The report and recommendations of ECVAM Workshop 52.
Tatiana I. Netzeva,Andrew Worth,Tom Aldenberg,Romualdo Benigni,Mark T. D. Cronin,Paola Gramatica,Joanna Jaworska,Scott Kahn,Gilles Klopman,Carol A. Marchant,Glenn J. Myatt,Nina Nikolova-Jeliazkova,Grace Patlewicz,Roger Perkins,David W. Roberts,Terry W Schultz,David T. Stanton,Johannes J.M. van de Sandt,Weida Tong,Gilman Veith,Chihae Yang +20 more
TL;DR: This is the 52nd report of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM) to provide a source of input to the development of an OECD Guidance Document on (Q)SAR Validation.
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Comparison of Cramer classification between Toxtree, the OECD QSAR Toolbox and expert judgment.
TL;DR: The Cramer class of over 1000 fragrance materials across diverse chemical classes were determined by using Toxtree, the OECD QSAR Toolbox, and expert judgment to determine the concordance within various chemical classes.
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Extension of the Dermal Sensitisation Threshold (DST) approach to incorporate chemicals classified as reactive
TL;DR: It is concluded that by combining the reactive DST with knowledge of chemistry a threshold can be established below which there is no appreciable risk of sensitisation for protein-reactive chemicals.
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Principles for identification of High Potency Category Chemicals for which the Dermal Sensitisation Threshold (DST) approach should not be applied.
TL;DR: The chemical properties and structural features of high potency sensitisers are discussed, and an approach whereby they can be identified and consequently excluded from application of the Dermal Sensitisation Threshold (DST) is derived.