Carol A. Mulrooney

TL;DR: Chiral 1,5-diaza-cis-decalins have been examined as ligands in the enantioselective oxidative biaryl coupling of substituted 2-naphthol derivatives and the relationship between the substitution of the naphthalene starting materials and reactivity/selectivity is determined.

TL;DR: A palladium-catalyzed aromatic decarboxylation reaction has been developed and was useful with complex functionalized substrates containing hindered carboxylic acids.

TL;DR: By using oxygen as the terminal oxidant, copper complexes derived from chiral 1,5-diaza-cis-decalin catalyze the enantioselective oxidative biaryl coupling of highly functionalized naphthols to provide octa- and decasubstituted binaphthalenes with high selectivity (86-90% ee).

TL;DR: An efficient and stereoselective total synthesis of the perylenequinone natural product hypocrellin A is described and the helical stereochemistry is formed from an axial chiral intermediate and is utilized in a dynamic stereochemical transfer to dictate the stereochemistry of the C7,C7'-seven membered ring formed during the aldol cyclization.

TL;DR: Mechanism studies of a mild palladium-catalyzed decarboxylation of aromatic carboxylic acids guided development of a catalytic system capable of turnover and reinforces that the second stage, protonation of the arylpalladium intermediate, is the rate-determining step of the reaction.