Carol Adaire Jones

TL;DR: It is demonstrated that mast cells can contribute to the development of multiple features of chronic asthma in mice and both Fc Rgamma-dependent and F c RGamma-independent pathways of mast cell activation are identified as important for the expression of key features of this asthma model.

TL;DR: Hematopoietic progenitor assays demonstrated that the differentiation potential of PV was already skewed toward the erythroid lineage at the HSC level, and the aberrant erytroid Potential of PV HSC was potently inhibited with a JAK2 inhibitor, AG490.

TL;DR: The morphological conversion in vitro of Chinese hamster ovary cells to a fibroblast form by a relatively large amount of dibutyryl adenosine cyclic 3':5'-monophosphate or by a combination of small amounts of this compound and testosterone appears useful in study of the regulation of phenotypic expression in mammalian cells.

TL;DR: A library of genomic DNA segments has been constructed from the DNA of a somatic cell hybrid carrying a portion of human chromosome 11 on a Chinese hamster ovary cell background, and using a nucleic acid hybridization technique that distinguishes human and Chinese hamsters interspersed, repetitive DNA, this approach promises implications for human genetics generally, for the human genetic diseases, and possibly for understanding of gene regulation in normal and abnormal differentiation.

TL;DR: Cloned DNA probes were used in combination with a panel of five hybrid cell clones containing a series of different terminal deletions in human chromosome 11 to map precisely the human hemoglobin beta and delta chain structural genes contained on this chromosome.