J
James L. Zehnder
Researcher at Stanford University
Publications - 285
Citations - 15335
James L. Zehnder is an academic researcher from Stanford University. The author has contributed to research in topics: Medicine & Transplantation. The author has an hindex of 52, co-authored 262 publications receiving 13513 citations. Previous affiliations of James L. Zehnder include United States Department of Veterans Affairs & University of California, San Diego.
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Journal ArticleDOI
Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response
Catherine S. Manno,Glenn F. Pierce,Valder R. Arruda,Bertil Glader,Margaret V. Ragni,Rasko Jj,Margareth C. Ozelo,Keith Hoots,Blatt P,Barbara A. Konkle,Michael D. Dake,Robin D. Kaye,Mahmood K. Razavi,A Zajko,James L. Zehnder,Pradip Rustagi,Hiroyuki Nakai,A Chew,Debra G.B. Leonard,Debra G.B. Leonard,J F Wright,Ruth Lessard,Jurg M. Sommer,Michael Tigges,Denise E. Sabatino,A Luk,Haiyan Jiang,Federico Mingozzi,Linda B. Couto,Hildegund C.J. Ertl,Katherine A. High,Katherine A. High,Mark A. Kay +32 more
TL;DR: In this article, a single portal vein infusion of a recombinant adeno-associated viral vector (rAAV) expressing canine Factor IX (F.IX) resulted in long-term expression of therapeutic levels of F.IX in dogs with severe hemophilia B.
Journal ArticleDOI
Granulocyte-Macrophage Progenitors as Candidate Leukemic Stem Cells in Blast-Crisis CML
Catriona Jamieson,Laurie Ailles,Scott J. Dylla,Manja Muijtjens,Carol D. Jones,James L. Zehnder,Jason Gotlib,Kevin Li,Markus G. Manz,Armand Keating,Charles L. Sawyers,Irving L. Weissman +11 more
TL;DR: Activation of beta-catenin in CML granulocyte-macrophage progenitors appears to enhance the self-renewal activity and leukemic potential of these cells.
Journal ArticleDOI
Ibrutinib in Previously Treated Waldenström’s Macroglobulinemia
Steven P. Treon,Christina K. Tripsas,Kirsten Meid,Diane Warren,Gaurav Varma,Rebecca Green,Kimon V. Argyropoulos,Guang Yang,Yang Cao,Lian Xu,Christopher J. Patterson,Scott J. Rodig,James L. Zehnder,Jon C. Aster,Nancy L. Harris,Sandra Kanan,Irene M. Ghobrial,Jorge J. Castillo,Jacob P. Laubach,Zachary R. Hunter,Zeena Salman,Jianling Li,Mei Cheng,Fong Clow,Thorsten Graef,M. Lia Palomba,Ranjana H. Advani +26 more
TL;DR: Ibrutinib was highly active, associated with durable responses, and safe in pretreated patients with Waldenström's macroglobulinemia, and the effect of MYD88 and CXCR4 mutations on outcomes was investigated.
Journal ArticleDOI
Gene expression patterns in human placenta
TL;DR: This study provides a rich and diverse picture of the molecular variation in the placenta from healthy pregnancies and identifies sets of genes whose expression in Placenta was significantly correlated with the sex of the fetus.
Journal ArticleDOI
Measurement and Clinical Monitoring of Human Lymphocyte Clonality by Massively Parallel V-D-J Pyrosequencing
Scott D. Boyd,Eleanor L. Marshall,Jason D. Merker,Jay M. Maniar,Lyndon N. Zhang,Bita Sahaf,Carol D. Jones,Birgitte B. Simen,Bozena Hanczaruk,Khoa D. Nguyen,Kari C. Nadeau,Michael Egholm,David B. Miklos,James L. Zehnder,Andrew Fire +14 more
TL;DR: It is shown that massively parallel DNA sequencing of rearranged immune receptor loci can provide direct detection and tracking of immune diversity and expanded clonal lymphocyte populations in physiological and pathological contexts.