C
Carola Gallo-Rodriguez
Researcher at Facultad de Ciencias Exactas y Naturales
Publications - 53
Citations - 1965
Carola Gallo-Rodriguez is an academic researcher from Facultad de Ciencias Exactas y Naturales. The author has contributed to research in topics: Adenosine receptor & Adenosine. The author has an hindex of 23, co-authored 52 publications receiving 1864 citations. Previous affiliations of Carola Gallo-Rodriguez include University of Buenos Aires & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Structure-Activity Relationships of N6-Benzyladenosine-5'-uronamides as A3-Selective Adenosine Agonists
Carola Gallo-Rodriguez,Xiao-duo Ji,Neli Melman,Siegman Bd,Sanders Lh,Orlina J,Bilha Fischer,Pu Q,Mark E. Olah,van Galen Pj +9 more
TL;DR: 5'-N-Methyluronamides and N6-(3-substituted-benzyl)adenosines are optimal for potency and selectivity at A3 receptors and a 4-methoxy group best favored A3 selectivity.
Journal ArticleDOI
8-(3-Chlorostyryl)caffeine (CSC) is a selective A2-adenosine antagonist in vitro and in vivo
Kenneth A. Jacobson,Olga Nikodijevic,William L. Padgett,Carola Gallo-Rodriguez,Michel Maillard,John W. Daly +5 more
TL;DR: Coadministration of CSC and the A1‐selective antagonist CPX, both at non‐stimulatory doses, increased activity by 37% (P < 0.001) over CSC alone, suggesting a behavioral synergism of A1 and A2‐antagonist effects in the CNS.
Journal Article
A Binding Site Model and Structure-Activity Relationships for the Rat A3 Adenosine Receptor
P. J. M. van Galen,A H van Bergen,Carola Gallo-Rodriguez,Neli Melman,Mark E. Olah,Adriaan P. IJzerman,Gary L. Stiles,Kenneth A. Jacobson +7 more
TL;DR: The model presented here, which is consistent with the detailed SAR found in this study, may serve to suggest future chemical modification, site-directed mutagenesis, and SAR studies to further define essential characteristics of the ligand-receptor interaction and to develop even more potent and selective A3 receptor ligands.
Journal Article
125I-4-aminobenzyl-5'-N-methylcarboxamidoadenosine, a high affinity radioligand for the rat A3 adenosine receptor.
TL;DR: This report characterizes 125I-4-aminobenzyl-5'-N-methylcarboxamidoadenosine (125I-AB-MECA), a high affinity radioligand for the A3AR, in two cell lines that express this AR subtype.
Journal ArticleDOI
Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonists.
Kenneth A. Jacobson,Carola Gallo-Rodriguez,Neli Melman,Bilha Fischer,Michel Maillard,Andrew van Bergen,Philip J. M. van Galen,Yishai Karton +7 more
TL;DR: 1,3,7-Trimethyl-8-[(3-carboxy-1-oxopropyl)amino] styryl]xanthine was highly A2-selective (250-fold) and of enhanced water solubility (max 19 mM) and 1,3-Dipropyl-7-methyl-8-(3,5-dimethoxystyryl) xanthines was a potent and very A2