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Adriaan P. IJzerman
Researcher at Leiden University
Publications - 417
Citations - 21007
Adriaan P. IJzerman is an academic researcher from Leiden University. The author has contributed to research in topics: Receptor & Adenosine receptor. The author has an hindex of 62, co-authored 399 publications receiving 18706 citations. Previous affiliations of Adriaan P. IJzerman include Utrecht University & Radboud University Nijmegen.
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Journal Article
International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors
TL;DR: Experiments with receptor antagonists and mice with targeted disruption of adenosine A(1), A(2A), and A(3) expression reveal roles for these receptors under physiological and particularly pathophysiological conditions.
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The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist.
Veli-Pekka Jaakola,Mark T. Griffith,Michael A. Hanson,Vadim Cherezov,Ellen Y.T. Chien,J. Robert Lane,Adriaan P. IJzerman,Raymond C. Stevens +7 more
TL;DR: The crystal structure of the human A2A adenosine receptor is determined, in complex with a high-affinity subtype-selective antagonist, ZM241385, to 2.6 angstrom resolution and suggests a role for ZM 241385 in restricting the movement of a tryptophan residue important in the activation mechanism of the class A receptors.
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International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update
TL;DR: In the 10 years since the previous International Union of Basic and Clinical Pharmacology report on the nomenclature and classification of adenosine receptors, no developments have led to major changes in the recommendations, but there have been so many other developments that an update is needed.
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Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions
Wei Liu,Eugene Chun,Aaron Thompson,Pavel Chubukov,Fei Xu,Vsevolod Katritch,Gye Won Han,Christopher B. Roth,Laura H. Heitman,Adriaan P. IJzerman,Vadim Cherezov,Raymond C. Stevens +11 more
TL;DR: The high-resolution structure of a stabilized version of the human A2Aadenosine receptor (A2AAR) reveals the position of about 60 internal waters, which suggests an almost continuous channel in the GPCR and can explain the allosteric effects of Na+ on ligand binding and how cholesterol may contribute to G PCR stabilization.
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International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B)
Stefan Offermanns,Steven L. Colletti,Timothy W. Lovenberg,Graeme Semple,Alan Wise,Adriaan P. IJzerman +5 more
TL;DR: The aim of this article is to give an overview on the discovery and pharmacological characterization of HCAs, and to introduce an International Union of Basic and Clinical Pharmacology (IUPHAR)-recommended nomenclature for this receptor family.