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Caroline Bäumler
Researcher at Boston Children's Hospital
Publications - 4
Citations - 2113
Caroline Bäumler is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Fas receptor & Interleukin 21. The author has an hindex of 4, co-authored 4 publications receiving 2100 citations. Previous affiliations of Caroline Bäumler include Heidelberg University.
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Journal ArticleDOI
Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)
Jens Dhein,Henning Walczak,Caroline Bäumler,Klaus-Michael Debatin,Peter H. Krammer,Peter H. Krammer +5 more
TL;DR: It is proposed that TCR-induced apoptosis in ATC can occur through an APO-1 ligand-mediated autocrine suicide, providing a mechanism for suppression of the immune response and for peripheral tolerance by T-cell deletion.
Journal ArticleDOI
The Role of APO-1-Mediated Apoptosis in the Immune System
Peter H. Krammer,Jens Dhein,Henning Walczak,Iris Behrmann,Sara M. Mariani,Bernd Matiba,Michael Fath,Peter T. Daniel,Eckart Knipping,Michael Westendorp,Kirstin Stricker,Caroline Bäumler,Stefan Hellbardt,Matthias Germer,Marcus E. Peter,Klaus‐Michael ‐M Debativ +15 more
TL;DR: B and T lymphocytes contact antigen at different stages of maturation and in a different cellular context, depending on these circumstances, their responses can be entirely different and the molecular switches leading to these different responses are partially unknown.
Journal ArticleDOI
Activation of the CD95 (APO-1/Fas) system in T cells from human immunodeficiency virus type-1-infected children.
Caroline Bäumler,Thomas Böhler,Ingrid Herr,Axel Benner,Peter H. Krammer,Klaus-Michael Debatin +5 more
TL;DR: Evidence is provided for a deregulated CD95 system inAIDS and an involvement of the CD95 receptor/ligand system in T-cell depletion and apoptosis in AIDS and may open new avenues of rational intervention strategies.
Journal ArticleDOI
Activation of the CD95 system increases with disease progression in human immunodeficiency virus type 1-infected children and adolescents
Thomas Böhler,Caroline Bäumler,Ingrid Herr,Andreas H. Groll,Marianne Kurz,Klaus-Michael Debatin +5 more
TL;DR: Disturbed regulation of the CD95 system may play an important role in the development of immunodeficiency during the course of HIV infection in children.