C
Caroline Charlier
Researcher at Université de Namur
Publications - 21
Citations - 963
Caroline Charlier is an academic researcher from Université de Namur. The author has contributed to research in topics: Docking (molecular) & Thrombin. The author has an hindex of 14, co-authored 21 publications receiving 885 citations. Previous affiliations of Caroline Charlier include University of Notre Dame & University of Auckland.
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Journal ArticleDOI
Dual inhibition of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) as a new strategy to provide safer non-steroidal anti-inflammatory drugs
TL;DR: In this review, COX and 5-LOX pathways are first described in order to highlight the therapeutic interest of designing such compounds.
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New COX-2/5-LOX inhibitors: apoptosis-inducing agents potentially useful in prostate cancer chemotherapy.
N Pommery,Thierry Taverne,Aurelie Telliez,Laurence Goossens,Caroline Charlier,Jean Pommery,Jean-François Goossens,R. Houssin,François Durant,Jean-Pierre Henichart +9 more
TL;DR: The synthesis and in vitro pharmacological properties of diarylpyrazole derivatives that have in their structure key pharmacophoric elements to obtain optimal interaction with subsites of active pockets in both enzyme systems are reported.
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Synthesis and Activity of a New Methoxytetrahydropyran Derivative as Dual Cyclooxygenase-2/5-Lipoxygenase Inhibitor
Sabine Barbey,Laurence Goossens,Thierry Taverne,Joséphine Cornet,Valérie Choesmel,Céline Rouaud,Gilles Gimeno,Sylvie Yannic-Arnoult,Catherine Michaux,Caroline Charlier,Raymond Houssin,Jean-Pierre Hénichart +11 more
TL;DR: A surprisingly potent effect of a 5-LO pharmacophoric group on the COX-2 inhibition is presented as well as pharmacological in vitro and in vivo results.
Journal ArticleDOI
Structural approach for COX-2 inhibition.
TL;DR: The drug design processes used to understand their binding mode and the origin of selectivity of these compounds are described and several families of such inhibitors were reported in literature.
Journal ArticleDOI
3,6-disubstituted coumarins as mechanism-based inhibitors of thrombin and factor Xa.
Raphaël Frédérick,Séverine Robert,Caroline Charlier,Jérôme de Ruyck,Johan Wouters,Bernard Pirotte,Bernard Masereel,Lionel Pochet +7 more
TL;DR: Coumarins were screened on thrombin (THR) and factor Xa (FXa), two of the most promising targets for the development of anticoagulant drugs, and compound 30, characterized by a 2,5-dichlorophenyl ester in the 3-position and a chloromethyl moiety in the 6-position, was highlighted as a very potent THR inhibitor.