C
Caroline Delmas
Researcher at French Institute of Health and Medical Research
Publications - 34
Citations - 1328
Caroline Delmas is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Radioresistance & RHOB. The author has an hindex of 18, co-authored 30 publications receiving 1116 citations. Previous affiliations of Caroline Delmas include Paul Sabatier University & University of Toulouse.
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Journal ArticleDOI
Ionizing radiations sustain glioblastoma cell dedifferentiation to a stem-like phenotype through survivin: possible involvement in radioresistance.
P Dahan,J. Martinez Gala,Caroline Delmas,Sylvie Monferran,Laure Malric,D. Zentkowski,Vincent Lubrano,Christine Toulas,E. Cohen-Jonathan Moyal,Anthony Lemarié +9 more
TL;DR: It is demonstrated that irradiation could regulate GBM cell dedifferentiation via a survivin-dependent pathway.
Journal ArticleDOI
Alphavbeta3 and alphavbeta5 integrins control glioma cell response to ionising radiation through ILK and RhoB.
Sylvie Monferran,Nicolas Skuli,Caroline Delmas,Gilles Favre,Jacques Bonnet,Elizabeth Cohen-Jonathan-Moyal,Christine Toulas +6 more
TL;DR: In this paper, the role of integrin activation and integrin signalling pathways controlled the glioma cell radiosensitivity to ionizing radiation, which was mediated through the integrin-linked kinase, ILK, and the small GTPase, RhoB.
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αvβ3/αvβ5 Integrins-FAK-RhoB: A Novel Pathway for Hypoxia Regulation in Glioblastoma
Nicolas Skuli,Sylvie Monferran,Caroline Delmas,Gilles Favre,Jacques Bonnet,Christine Toulas,Elizabeth Cohen-Jonathan Moyal +6 more
TL;DR: The present results unravel a new mechanism of hypoxia regulation by establishing the existence of an alpha(v)beta(3) and alpha( v) beta(5) integrin-dependent loop of Hypoxia autoregulation in glioma, which may be crucial to optimizing radiotherapy efficiency.
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Farnesyltransferase inhibitor, R115777, reverses the resistance of human glioma cell lines to ionizing radiation.
Caroline Delmas,Christophe Heliez,Elizabeth Cohen-Jonathan,Dave W. End,Jacques Bonnet,Gilles Favre,Christine Toulas +6 more
TL;DR: It is demonstrated that RhoB, but not Ras, is implicated in glioma radioresistance, and the R115777 differential radiosensitizer effect underlines the potential therapeutic interest of using this drug as a radiosensitizeder of humanglioma.
Journal ArticleDOI
Activation of RhoB by Hypoxia Controls Hypoxia-Inducible Factor-1α Stabilization through Glycogen Synthase Kinase-3 in U87 Glioblastoma Cells
Nicolas Skuli,Sylvie Monferran,Caroline Delmas,Isabelle Lajoie-Mazenc,Gilles Favre,Christine Toulas,Elizabeth Cohen-Jonathan-Moyal +6 more
TL;DR: The results have shown the early activation of RhoB by reactive oxygen species under hypoxic conditions and, subsequently, its participation in the ensuing cellular adaptation to hypoxia, and strongly implicate Rho B as a potentially important therapeutic target for decreasing tumor Hypoxia.