C
Caroline E. Brun
Researcher at Ottawa Hospital Research Institute
Publications - 21
Citations - 1303
Caroline E. Brun is an academic researcher from Ottawa Hospital Research Institute. The author has contributed to research in topics: Stem cell & Skeletal muscle. The author has an hindex of 9, co-authored 15 publications receiving 855 citations. Previous affiliations of Caroline E. Brun include University of Ottawa.
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Journal ArticleDOI
Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division
Nicolas A. Dumont,Nicolas A. Dumont,Yu Xin Wang,Yu Xin Wang,Julia von Maltzahn,Julia von Maltzahn,Alessandra Pasut,Alessandra Pasut,C. Florian Bentzinger,C. Florian Bentzinger,Caroline E. Brun,Caroline E. Brun,Michael A. Rudnicki,Michael A. Rudnicki +13 more
TL;DR: It is concluded that dystrophin has an essential role in the regulation of satellite cell polarity and asymmetric division, and muscle wasting in DMD not only is caused by myofiber fragility, but also is exacerbated by impaired regeneration owing to intrinsic satellite cell dysfunction.
Journal ArticleDOI
The myogenic regulatory factors, determinants of muscle development, cell identity and regeneration.
J. Manuel Hernández-Hernández,Estela G. García-González,Caroline E. Brun,Michael A. Rudnicki,Michael A. Rudnicki +4 more
TL;DR: Application of combined functional genomics technologies along with single cell lineage tracing strategies will allow a deeper understanding of the mechanisms mediating myogenic determination, cell differentiation and muscle regeneration.
Journal ArticleDOI
Orienting Muscle Stem Cells for Regeneration in Homeostasis, Aging, and Disease
Peter Feige,Peter Feige,Caroline E. Brun,Caroline E. Brun,Morten Ritso,Morten Ritso,Michael A. Rudnicki,Michael A. Rudnicki +7 more
TL;DR: The relationship of satellite cell heterogeneity and the establishment of polarity to asymmetric division is discussed, as well as how these processes are impacted in homeostasis, aging, and disease.
Journal ArticleDOI
Concise Review: Epigenetic Regulation of Myogenesis in Health and Disease
Marie-Claude Sincennes,Caroline E. Brun,Caroline E. Brun,Michael A. Rudnicki,Michael A. Rudnicki +4 more
TL;DR: Recent findings on epigenetic regulation in satellite stem cells and committed myoblasts are described and the potential of epigenetic drugs, such as HDAC inhibitors, as well as their molecular mechanism of action in muscle cells, will be addressed.
Journal ArticleDOI
The Dystrophin Glycoprotein Complex Regulates the Epigenetic Activation of Muscle Stem Cell Commitment.
Natasha C. Chang,Marie-Claude Sincennes,Marie-Claude Sincennes,Fabien P. Chevalier,Fabien P. Chevalier,Caroline E. Brun,Caroline E. Brun,Melanie Lacaria,Melanie Lacaria,Jessica Segalés,Pura Muñoz-Cánoves,Hong Ming,Hong Ming,Michael A. Rudnicki,Michael A. Rudnicki +14 more
TL;DR: Dysregulation of p38γ/Carm1 results in altered epigenetic gene regulation in Duchenne muscular dystrophy and the resulting progenitors exhibit reduced Carm1 binding to Pax7, reduced H3K4-methylation of chromatin, and reduced transcription of Myf5 and other Pax7 target genes.