Jessica Segalés

TL;DR: This study provides an important description of a unique unexpected role of Mfn2 coordinating mitochondria and endoplasmic reticulum function, leading to modulation of insulin signaling and glucose homeostasis in vivo.

TL;DR: The findings reveal that Mfn2 repression in muscle during aging is a determinant for the inhibition of mitophagy and accumulation of damaged mitochondria and triggers the induction of a mitochondrial quality control pathway.

TL;DR: It is proposed that mitochondrial fusion proteins operate as integrators of signals so they regulate both mitochondrial fusion and metabolism and loss-of-function reduces oxygen consumption and the capacity to oxidize substrates.

TL;DR: A review of the molecular mechanisms implicated in the transition of satellite cells throughout the distinct myogenic stages and on how the p38 MAPK signaling pathway integrates the environmental signals at the chromatin to build up satellite cell adaptive responses during the process of muscle regeneration, and how these responses are altered in aging.

TL;DR: Dysregulation of p38γ/Carm1 results in altered epigenetic gene regulation in Duchenne muscular dystrophy and the resulting progenitors exhibit reduced Carm1 binding to Pax7, reduced H3K4-methylation of chromatin, and reduced transcription of Myf5 and other Pax7 target genes.