C
Caroline M. Bateman
Researcher at Institute of Cancer Research
Publications - 15
Citations - 1273
Caroline M. Bateman is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 8, co-authored 9 publications receiving 1186 citations.
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Journal ArticleDOI
Genetic variegation of clonal architecture and propagating cells in leukaemia
Kristina Anderson,Christoph Lutz,Frederik W. van Delft,Caroline M. Bateman,Yan-Ping Guo,Susan M. Colman,Helena Kempski,Anthony V. Moorman,Ian Titley,John Swansbury,Lyndal Kearney,Tariq Enver,Tariq Enver,Mel Greaves +13 more
TL;DR: This issue is examined in childhood acute lymphoblastic leukaemia in which the ETV6–RUNX1 gene fusion is an early or initiating genetic lesion followed by a modest number of recurrent or ‘driver’ copy number alterations.
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Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia.
Lyndal Kearney,David Gonzalez de Castro,Jenny Yeung,Julia Procter,Sharon W. Horsley,Minenori Eguchi-Ishimae,Minenori Eguchi-Ishimae,Caroline M. Bateman,Kristina Anderson,Tracy Chaplin,Bryan D. Young,Christine J. Harrison,Helena Kempski,Chi Wai Eric So,Anthony M. Ford,Mel Greaves +15 more
TL;DR: A complex molecular pathogenesis for DS-ALL leukemogenesis is infer, with trisomy 21 as an initiating or first hit and with chromosome aneuploidy, gene deletions, and activating JAK2 mutations as complementary genetic events.
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Clonal origins of relapse in ETV6-RUNX1 acute lymphoblastic leukemia.
Frederik W. van Delft,Sharon W. Horsley,Sue Colman,Kristina Anderson,Caroline M. Bateman,Helena Kempski,Jan Zuna,Cornelia Eckert,Vaskar Saha,Lyndal Kearney,Anthony M. Ford,Mel Greaves +11 more
TL;DR: Subclonal diversity at diagnosis is indicated, providing a variable basis for intraclonal origins of relapse and extended periods (years) of dormancy, possibly by quiescence, for stem cells in ETV6-RUNX1(+) acute lymphoblastic leukemia.
Journal ArticleDOI
Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia
Caroline M. Bateman,Susan M. Colman,Tracy Chaplin,Bryan D. Young,Tim Eden,Manoo Bhakta,Eric J. Gratias,Elisabeth R. van Wering,Giovanni Cazzaniga,Christine J. Harrison,Richard Hain,Philip Ancliff,Anthony M. Ford,Lyndal Kearney,Mel Greaves +14 more
TL;DR: These data place all "driver" CNAs secondary to the prenatal gene fusion event and most probably postnatal in the sequential, molecular pathogenesis of ALL.
Journal ArticleDOI
Evolutionary trajectories of hyperdiploid ALL in monozygotic twins
Caroline M. Bateman,Donát Alpár,Anthony M. Ford,Susan M. Colman,D. Wren,Mary Morgan,Lyndal Kearney,Mel Greaves +7 more
TL;DR: It is proposed that hyperdiploid ALL arises in a pre-B cell in utero and mutational changes necessary for clinical ALL accumulate subclonally and postnatally.