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Caroline Scholtes
Researcher at University of Lyon
Publications - 78
Citations - 1416
Caroline Scholtes is an academic researcher from University of Lyon. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 17, co-authored 63 publications receiving 984 citations. Previous affiliations of Caroline Scholtes include École normale supérieure de Lyon & HCL Technologies.
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Serum hepatitis B core-related antigen (HBcrAg) correlates with covalently closed circular DNA transcriptional activity in chronic hepatitis B patients.
Barbara Testoni,Barbara Testoni,Fanny Lebossé,Fanny Lebossé,Caroline Scholtes,Caroline Scholtes,Françoise Berby,Clothilde Miaglia,Clothilde Miaglia,Miroslava Subic,Alessandro Loglio,Floriana Facchetti,Pietro Lampertico,Massimo Levrero,Fabien Zoulim,Fabien Zoulim +15 more
TL;DR: It is demonstrated that quantification of hepatitis B core-related antigen in serum correlates with cccDNA amount and activity and could be used to monitor disease progression and develop new antiviral treatments directly targeting the intrahepatic pool of ccc DNA.
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Secretion of Hepatitis C Virus Envelope Glycoproteins Depends on Assembly of Apolipoprotein B Positive Lipoproteins
Vinca Icard,Olivier Diaz,Olivier Diaz,Caroline Scholtes,Laure Perrin-Cocon,Laure Perrin-Cocon,Christophe Ramière,Ralf Bartenschlager,François Penin,Vincent Lotteau,Patrice Andre +10 more
TL;DR: Data indicate that HCV envelope glycoproteins have the intrinsic capacity to utilize apoB synthesis and lipoprotein assembly machinery even in the absence of the other HCV proteins.
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Evaluation of NGS-based approaches for SARS-CoV-2 whole genome characterisation
Caroline Charre,Caroline Charre,Christophe Ginevra,Marina Sabatier,Hadrien Regue,Grégory Destras,Solenne Brun,Gwendolyne Burfin,Caroline Scholtes,Caroline Scholtes,Florence Morfin,Martine Valette,Bruno Lina,Antonin Bal,Laurence Josset +14 more
TL;DR: A loss of coverage in any given region of the genome should alert to a potential rearrangement or a SNP in primer-annealing or probe-hybridizing regions and would require further validation using unbiased metagenomic sequencing.
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Hepatitis E virus mutations associated with ribavirin treatment failure result in altered viral fitness and ribavirin sensitivity
Yannick Debing,Christophe Ramière,Kai Dallmeier,Géraldine Piorkowski,Mary-Anne Trabaud,Fanny Lebossé,Caroline Scholtes,Magali Roche,Catherine Legras-Lachuer,Xavier de Lamballerie,Patrice Andre,Johan Neyts +11 more
TL;DR: A patient with chronic hepatitis E experiencing ribavirin treatment failure with a completely resistant phenotype is presented and viral mutations associated with treatment failure are identified and investigated to investigate the underlying causes of treatment failure.
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Transactivation of the Hepatitis B Virus Core Promoter by the Nuclear Receptor FXRα
C. Ramière,Caroline Scholtes,Olivier Diaz,Vinca Icard,Laure Perrin-Cocon,Mary-Anne Trabaud,Vincent Lotteau,Patrice Andre +7 more
TL;DR: The data strongly suggest that FXRα is another member of the nuclear receptor superfamily implicated in the regulation ofHBV core promoter activity and that bile acids could play an important role in the natural history of HBV infection.