Caroline Sommereyns

TL;DR: Plasmid electrotransfer-mediated in vivo expression of individual IFN genes allowed the tissue and cell specificities of the responses to systemic IFn-α/β and IFN-λ to be compared.

TL;DR: It is shown that activation of this receptor by IFN-lambda 1 can also inhibit cell proliferation and induce STAT4 phosphorylation, further extending functional similarities with type I IFNs and shed some new light on the mechanisms of activation of STAT2 and STAT4 by these cytokines.

TL;DR: The data indicate that Paneth cell hyperplasia and expression of their various antimicrobial products contribute to the immune response driven by TH2 cytokines, such as IL-9 and IL-13 in the intestinal mucosa.

TL;DR: Increased glucose metabolism by itself does not trigger NADPH oxidase activation, although PPP is required to provide NOX2 with NADPH and to produce ROS, suggesting that an extracellular metabolic signal transduces into an intracellular ionic signal.

TL;DR: This review is dedicated to the influence of type I IFNs (also called IFN-alpha/beta) in the central nervous system (CNS), which appear to be crucial in limiting early spread of a number of viruses in CNS tissues.