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Sandrine Horman
Researcher at Université catholique de Louvain
Publications - 119
Citations - 5182
Sandrine Horman is an academic researcher from Université catholique de Louvain. The author has contributed to research in topics: AMPK & AMP-activated protein kinase. The author has an hindex of 35, co-authored 90 publications receiving 4487 citations. Previous affiliations of Sandrine Horman include Université libre de Bruxelles & Catholic University of Leuven.
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Journal ArticleDOI
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders
Benoit Viollet,Marc Foretz,Bruno Guigas,Sandrine Horman,Renaud Dentin,Luc Bertrand,Louis Hue,Fabrizio Andreelli +7 more
TL;DR: Findings reinforce the idea that pharmacological activation of AMPK may provide, through signalling and metabolic and gene expression effects, a new strategy for the management of metabolic hepatic disorders linked to type 2 diabetes and obesity.
Journal ArticleDOI
Activation of AMP-Activated Protein Kinase Leads to the Phosphorylation of Elongation Factor 2 and an Inhibition of Protein Synthesis
Sandrine Horman,Gareth J. Browne,Ulrike Krause,J. V. Patel,Didier Vertommen,Luc Bertrand,A. Lavoinne,Louis Hue,Christopher G. Proud,Mark H. Rider +9 more
TL;DR: The activation of e EF2 kinase by AMPK, resulting in the phosphorylation and inactivation of eEF2, provides a novel mechanism for the inhibition of protein synthesis.
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AMPK inhibition in health and disease.
Benoit Viollet,Sandrine Horman,Jocelyne Leclerc,Louise Lantier,Marc Foretz,Marc Billaud,Shailendra Giri,Fabrizio Andreelli +7 more
TL;DR: This review discusses recent findings that support the role and function of AMPK inhibition under physiological and pathological states and discusses the importance of whole body energy homeostasis.
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Insulin Antagonizes Ischemia-induced Thr172 Phosphorylation of AMP-activated Protein Kinase α-Subunits in Heart via Hierarchical Phosphorylation of Ser485/491
Sandrine Horman,Didier Vertommen,Richard Heath,Dietbert Neumann,Véronique Mouton,Aangela Woods,Uwe Schlattner,Theo Wallimann,David Carling,Louis Hue,Mark H. Rider +10 more
TL;DR: It is proposed that the effect of insulin to antagonize AMP-activatedprotein kinase activation involves a hierarchical mechanism whereby Ser485/Ser491 phosphorylation by protein kinase B reduces subsequent phosphorylated of Thr172 by LKB1 and the resulting activation of AMp-activated protein Kinase.
Journal ArticleDOI
AMPK: Lessons from transgenic and knockout animals.
Benoit Viollet,Yoni Athea,Rémi Mounier,Bruno Guigas,Elham Zarrinpashneh,Sandrine Horman,Louise Lantier,Sophie Hébrard,Jocelyne Devin-Leclerc,Christophe Beauloye,Marc Foretz,Fabrizio Andreelli,Renée Ventura-Clapier,Luc Bertrand +13 more
TL;DR: Recent findings obtained from animal models with inhibition or activation of AMPK signaling pathway are discussed, including developments in transgenic and knockout mouse models.