Carolyn A. Michael

TL;DR: It is proposed that in addition to current measures and increased research into new antimicrobials and diagnostics, a comprehensive education program will be required to change the public paradigm of antimicrobial usage from that of a first line treatment to that of an last resort when all other therapeutic options have failed.

TL;DR: To estimate the diversity of mobile cassettes in a natural environment, a molecular technique was developed to provide representative distributions of cassette populations at points within a sampling area and statistical methods analogous to those used for calculating species diversity were employed.

TL;DR: Analysis of sequenced V. cholerae integron arrays showed that their evolution can proceed by rearrangements and deletions/insertions of large portions of M GCs in addition to the insertion or excision of single MGCs, providing further evidence that these strains have evolved from a common progenitor.

TL;DR: These findings explained the existence and maintenance of large cassette arrays within many prokaryotes and suggested that repeated rearrangement of cassettes containing genes and/or promoters within large arrays could result in the assembly of operon-like groups of co-expressed cassettes within an array.

TL;DR: It is advocated that antibiotic resistance be reframed as a disaster risk management problem, and public perception of antibiotic resistance as an important issue that warrants exploration is identified.