H
Harold W. Stokes
Researcher at Macquarie University
Publications - 29
Citations - 1935
Harold W. Stokes is an academic researcher from Macquarie University. The author has contributed to research in topics: Integron & Gene. The author has an hindex of 23, co-authored 29 publications receiving 1811 citations. Previous affiliations of Harold W. Stokes include University of Technology, Sydney.
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Journal ArticleDOI
Gene cassette PCR: sequence-independent recovery of entire genes from environmental DNA.
Harold W. Stokes,Andrew J. Holmes,Blair S Nield,Marita Holley,Helena Nevalainen,Bridget C. Mabbutt,Michael R. Gillings +6 more
TL;DR: The success of this approach indicates that mobile gene cassettes and, by inference, integrons are widespread in natural environments and are likely to contribute significantly to bacterial diversity.
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Recovery of new integron classes from environmental DNA
Blair S Nield,Andrew J. Holmes,Michael R. Gillings,Gavin D. Recchia,Bridget C. Mabbutt,Helena Nevalainen,Harold W. Stokes +6 more
TL;DR: Since they are derived from environments not associated with antibiotic use, integrons appear to be more prevalent in bacteria than previously observed.
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The gene cassette metagenome is a basic resource for bacterial genome evolution
Andrew J. Holmes,Michael R. Gillings,Blair S Nield,Bridget C. Mabbutt,K. M. Helena Nevalainen,Harold W. Stokes +5 more
TL;DR: It is proposed that gene cassettes represent a vast, prepackaged genetic resource that could be thought of as a metagenomic template for bacterial evolution.
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Class 1 Integrons Potentially Predating the Association with Tn402-Like Transposition Genes Are Present in a Sediment Microbial Community
Harold W. Stokes,Camilla L. Nesbø,Marita Holley,Martin Iain Bahl,Michael R. Gillings,Yan Boucher +5 more
TL;DR: It is concluded that novel class 1 integrons are present in a sediment environment in various bacteria of the β-proteobacterial class, suggesting that the dispersal of this class may have begun before the “antibiotic era.”
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Are humans increasing bacterial evolvability
TL;DR: Saturation of the environment with selective agents might cause directional selection for higher rates of mutation, recombination and LGT, producing unpredictable consequences for humans and the biosphere.