C
Carolyn K. Suzuki
Researcher at Rutgers University
Publications - 46
Citations - 2939
Carolyn K. Suzuki is an academic researcher from Rutgers University. The author has contributed to research in topics: Mitochondrion & Mitochondrial DNA. The author has an hindex of 24, co-authored 41 publications receiving 2630 citations. Previous affiliations of Carolyn K. Suzuki include University of Medicine and Dentistry of New Jersey & University of Basel.
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Journal ArticleDOI
Requirement for the yeast gene LON in intramitochondrial proteolysis and maintenance of respiration
TL;DR: The role of protein degradation in mitochondrial homeostasis was explored by cloning of a gene from Saccharomyces cerevisiae that encodes a protein resembling the adenosine triphosphate (ATP)-dependent bacterial protease Lon, which has a typical mitochondrial matrix-targeting sequence at its amino terminus.
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Phosphorylation of human TFAM in mitochondria impairs DNA binding and promotes degradation by the AAA+ Lon protease
Bin Lu,Jae Lee,Xiaobo Nie,Min Li,Yaroslav I. Morozov,Sundararajan Venkatesh,Daniel F. Bogenhagen,Dmitry Temiakov,Carolyn K. Suzuki +8 more
TL;DR: It is demonstrated that TFAM is phosphorylated within its HMG box 1 (HMG1) by cAMP-dependent protein kinase in mitochondria, which provides mechanisms for rapid fine-tuning of TFAM function and abundance in mitochondaria, which are crucial for maintaining and expressing mtDNA.
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ATP-dependent proteases that also chaperone protein biogenesis
Carolyn K. Suzuki,Martijn Rep,van Jan Maarten Dijl,Kitaru Suda,Leslie A. Grivell,Gottfried Schatz +5 more
TL;DR: The ATP-dependent proteases Clp and FTSH from bacteria, as well as mitochondrial homologs of FtsH and Lon from yeast, may act as chaperones; they mediate not only proteolysis, but also the insertion of proteins into membranes and the disassembly or oligomerization of protein complexes.
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Promotion of Mitochondrial Membrane Complex Assembly by a Proteolytically Inactive Yeast Lon
Martijn Rep,van Jan Maarten Dijl,Kitaru Suda,Gottfried Schatz,Leslie A. Grivell,Carolyn K. Suzuki +5 more
TL;DR: It is suggested that the mitochondrial proteases Lon, Afg3p, and Rca1p can also serve a chaperone-like function in the assembly of mitochondrial protein complexes.
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Multitasking in the mitochondrion by the ATP-dependent Lon protease ☆
TL;DR: An overview of the diverse functions of mitochondrial Lon is presented, as well as speculative perspectives on its role in protein and mtDNA quality control.