C
Caryn Naekyung Kim
Researcher at Emory University
Publications - 12
Citations - 11744
Caryn Naekyung Kim is an academic researcher from Emory University. The author has contributed to research in topics: Apoptosis & Cytochrome c. The author has an hindex of 11, co-authored 12 publications receiving 11468 citations. Previous affiliations of Caryn Naekyung Kim include University of South Florida.
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Journal ArticleDOI
Induction of apoptotic program in cell-free extracts : requirement for datp and cytochrome c
TL;DR: Cells undergoing apoptosis in vivo showed increased release of cy tochrome c to their cytosol, suggesting that mitochondria may function in apoptosis by releasing cytochrome c.
Journal ArticleDOI
Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
Jie Yang,Xuesong Liu,Xuesong Liu,Kapil N. Bhalla,Caryn Naekyung Kim,Ana Maria Ibrado,Jiyang Cai,Tsung I. Peng,Dean P. Jones,Xiaodong Wang,Xiaodong Wang +10 more
TL;DR: One possible role of Bcl-2 in prevention of apoptosis is to block cytochrome c release from mitochondria, which is normally located in the mitochondrial intermembrane space.
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Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling.
Siddharth Balachandran,Caryn Naekyung Kim,Wen Chen Yeh,Tak W. Mak,Kapil N. Bhalla,Glen N. Barber +5 more
TL;DR: In this article, a tetracycline-inducible murine cell lines that express wild-type protein kinase (PKR) or a catalytically inactive PKR variant, PKRdelta6 were developed.
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Bcr-Abl Exerts Its Antiapoptotic Effect Against Diverse Apoptotic Stimuli Through Blockage of Mitochondrial Release of Cytochrome C and Activation of Caspase-3
Gustavo P. Amarante-Mendes,Caryn Naekyung Kim,Linda Liu,Yue Huang,Charles L. Perkins,Douglas R. Green,Kapil N. Bhalla +6 more
TL;DR: Findings indicate that Bcr-Abl expression blocks apoptosis due to diverse apoptotic stimuli upstream by preventing the cytosolic accumulation of cyt c and other preapoptotic mitochondrial perturbations, thereby inhibiting the activation of caspase-3 and execution of apoptosis.
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CGP57148B (STI-571) induces differentiation and apoptosis and sensitizes Bcr-Abl-positive human leukemia cells to apoptosis due to antileukemic drugs
Guofu Fang,Caryn Naekyung Kim,Charles L. Perkins,Nimmanapalli Ramadevi,Elliott Winton,Sylvie Wittmann,Kapil N. Bhalla +6 more
TL;DR: In vitro data indicate that combinations of CGP57148B and antileukemic drugs such as Ara-C may have improved in vivo efficacy against Bcr-Abl-positive acute leukemia.