Showing papers in "Blood in 1998"

TL;DR: Subgroup analysis demonstrated that the three cytogenetically defined prognostic groups retained their predictive value in the context of secondary as well as de novo AML, within the pediatric age group and furthermore were found to be a key determinant of outcome from autologous or allogeneic bone marrow transplantation (BMT) in first CR.

TL;DR: The membrane has long been viewed as an inert cellophane-like membrane that lines the circulatory system with its primary essential function being the maintenance of vessel wall permeability.

TL;DR: Preliminary data in 26 patients with standard indications for allogeneic BMT suggest that nonmyeloablative conditioning including fludarabine, anti-T-lymphocyte globulin, and low-dose busulfan is extremely well tolerated, with no severe procedure-related toxicity.

TL;DR: It is demonstrated that a subset of CD34(+) cells have the capacity to differentiate into endothelial cells in vitro in the presence of basic fibroblast growth factor, insulin-like growth factor-1, and vascular endothelial growth factor.

TL;DR: The highest rates of prevalence of CVA and incidence were in sickle cell anemia (SS) patients, but CVA occurred in all common genotypes, and the incidence of infarctive CVA was lowest in SS patients 20 to 29 years of age and higher in children and older patients.

TL;DR: Neutrophils are one of the professional phagocytes in humans that ingest bacteria into intracellular spaces and are involved in phagocytosis.

TL;DR: Polyclonal donor-derived T-cell lines specific for EBV proteins can be used safely to prevent EBV-related immunoblastic lymphoma after allogeneic marrow transplantation and may also be effective in the treatment of established disease.

TL;DR: In this first trial of rituximab in DLCL and MCL, patients experienced a significant clinical activity with a low toxicity and should be tested in combination with chemotherapy in such patients.

TL;DR: The data suggest that VEGF, at pathologically relevant concentrations in vivo, may exert effects on pluripotent stem cells that result in blocked DC development as well as affect many other hematopoietic lineages.

TL;DR: Results demonstrate that murine CML recapitulates important features of human CML and should be an excellent model for addressing specific issues relating to the pathogenesis and treatment of this disease.

TL;DR: The daily turnover in a normal adult of approximately 1012 blood cells is tightly regulated, involving hematopoietic progenitor cells and mature blood cells from a pool of pluripotent, long-term reconstituting stem cells.

TL;DR: A clonal B-cell neoplasm that affects terminally differentiated B cells (ie, plasma cells) and may proceed through different phases: an inactive phase in which tumor cells are nonproliferating mature plasma cells, an active phase with a small percentage (<1%) of tumor cells.

TL;DR: Although larger prospective studies are required before firm conclusions can be reached, these studies show the expression in B-CLLs of multiple apoptosis-regulating proteins and suggest that the relative levels of some of these, such as Mcl-1, may provide information about in vivo responses to chemotherapy.

TL;DR: This work has shown that vascular damage triggers reparative processes, such as hemostasis, inflammation, and wound healing, which depend on a coordinated series of cell growth, differentiation, survival, and function.

TL;DR: Functional studies in a mutant cell line expressing neither HIF-1alpha nor EPAS-1 confirmed that both proteins interact with hypoxically responsive targets, but suggest target specificity with greater EPas-1 transactivation of the VEGF promoter than the LDH-A promoter.

TL;DR: It is concluded that CXCR-4 is expressed on CD34+ cells including more primitive, pluripotent progenitors, and may therefore play a role in the homing of hematopoietic stem cells.

TL;DR: It is suggested that ligation of CD20 in vivo by anti-CD20 antibodies in the presence of FcR-expressing cells may initiate signal transduction events that induce elevation of [Ca2+]i and lead to apoptosis of malignant B cells, thereby contributing to the impressive tumor regressions observed in mouse models and clinical trials using anti- CD20 MoAbs.

TL;DR: The results suggest that the inhibition of DC development could represent a frequent mechanism by which tumor cells will escape immune recognition.

TL;DR: Data show specific involvement of the CD95-CD95L system in the anti-cancer activity of resveratrol and highlight the chemotherapeutic potential of this natural product, in addition to its recently reported chemopreventive activity.

TL;DR: In this paper, the authors investigated whether in vivo infusion of recombinant VEGF could reproduce the observed defective function of dendritic cells (DC) in cancer, and they found that continuous infusion, at rates as low as 50 ng/h, resulted in a dramatic inhibition of DC development, associated with an increase in the production of B cells and immature Gr-1+ myeloid cells.

TL;DR: The results show the superiority of tacrolimus/methotrexate over cyclosporine/mETHOTrexate in the prevention of grade II-IV acute GVHD with no difference in disease-free or overall survival in patients with nonadvanced disease.

TL;DR: HDR with PBSC transplantation obtained a median OS exceeding 5 years in young patients with symptomatic MM, whether performed early, as first-line therapy, or late, as rescue treatment, suggesting early HDT may be preferred because it is associated with a shorter period of chemotherapy.

TL;DR: Although the poor prognosis of non-ALCL PTCL could be due in part to the presence of adverse prognostic factors at diagnosis, this study shows that the T-cell phenotype is an independent significant factor, which should be incorporated into the definition of prognostic groups.

TL;DR: In 1948, Bernard and SOULIER described a young male patient with a severe bleeding disorder that was characterized by a prolonged bleeding time, thrombocytopenia, and extremely large platelets.

TL;DR: The data show the complex nature of molecular events in DLCL, which is a reflection of the morphologic and clinical heterogeneity of these lymphomas, and thus far, these genetic rearrangements fail as prognostic markers.

TL;DR: It is hypothesized that dysregulation of MMSET contributes to neoplastic transformation in MM with t(4;14) translocation, the first example of an IgH translocation that simultaneously dysregulates two genes with oncogenic potential.

TL;DR: This work states that the current understanding of the molecular basis of hemophilia A, which has already been documented as a familial bleeding tendency in the fifth century, still persists as the most common hemorrhagic disorder.

TL;DR: It is concluded that matching HLA class I and class II alleles of the donor and recipient can improve outcome after unrelated marrow transplantation.

TL;DR: It is concluded from this study that ALK-positive neoplasms represent a distinct entity and should henceforward be referred to as ALK lymphomas.

TL;DR: These in vitro migration experiments suggest that chemoattractants such as SDF-1 and SLF with other unidentified BM chemoATTractants may be involved cooperatively in the migration of HPC to the BM and in preventing spontaneous mobilization of H PC out of the BM.