C
Cassie L. Dohrn
Researcher at Roy J. and Lucille A. Carver College of Medicine
Publications - 20
Citations - 1930
Cassie L. Dohrn is an academic researcher from Roy J. and Lucille A. Carver College of Medicine. The author has contributed to research in topics: Pneumococcal infections & Streptococcus pneumoniae. The author has an hindex of 16, co-authored 20 publications receiving 1784 citations.
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Journal ArticleDOI
Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth
David A. Stoltz,David K. Meyerholz,Alejandro A. Pezzulo,Shyam Ramachandran,Mark P. Rogan,Greg J. Davis,Robert A. Hanfland,Chris Wohlford-Lenane,Cassie L. Dohrn,Jennifer A. Bartlett,George A. Nelson,Eugene H. Chang,Peter J. Taft,Paula S. Ludwig,Mira Estin,Emma E. Hornick,Janice L. Launspach,Melissa Samuel,Tatiana Rokhlina,Philip H. Karp,Lynda S. Ostedgaard,Aliye Uc,Timothy D. Starner,Alexander R. Horswill,Kim A. Brogden,Randall S. Prather,Sandra S. Richter,Joel Shilyansky,Paul B. McCray,Joseph Zabner,Michael J. Welsh +30 more
TL;DR: Findings in cystic fibrosis pigs that survive long enough to develop human-like lung disease are reported, suggesting that impaired bacterial elimination is the pathogenic event that initiates a cascade of inflammation and pathology in CF lungs.
Journal ArticleDOI
The ΔF508 Mutation Causes CFTR Misprocessing and Cystic Fibrosis-Like Disease in Pigs
Lynda S. Ostedgaard,David K. Meyerholz,Jeng-Haur Chen,Alejandro A. Pezzulo,Philip H. Karp,Tatiana Rokhlina,Sarah E. Ernst,Robert A. Hanfland,Leah R. Reznikov,Paula S. Ludwig,Mark P. Rogan,Greg J. Davis,Cassie L. Dohrn,Christine L. Wohlford-Lenane,Peter J. Taft,Michael V. Rector,Emma E. Hornick,Boulos Nassar,Melissa Samuel,Yuping Zhang,Sandra S. Richter,Aliye Uc,Joel Shilyansky,Randall S. Prather,Paul B. McCray,Joseph Zabner,Michael J. Welsh,David A. Stoltz +27 more
TL;DR: Pigs may provide a better model of CF because they have more similar anatomy, biochemistry, physiology, size, and genetics to humans than mice, and this new model may help to determine which levels of CFTR are sufficient for function and, therefore, guide future therapeutic strategies.
Journal ArticleDOI
Pneumococcal serotypes before and after introduction of conjugate vaccines, United States, 1999-2011(1.).
Sandra S. Richter,Kristopher P. Heilmann,Cassie L. Dohrn,Fathollah Riahi,Daniel J. Diekema,Gary V. Doern +5 more
TL;DR: Data show that introduction of the 7-valent vaccine has dramatically decreased prevalence of its serotypes and that addition of serotypes in PCV13 could provide coverage of 39% of isolates that continue to cause disease.
Pneumococcal Serotypes before and after Introduction of Conjugate Vaccines
Journal ArticleDOI
Changing Epidemiology of Antimicrobial-Resistant Streptococcus pneumoniae in the United States, 2004–2005
Sandra S. Richter,Kristopher P. Heilmann,Cassie L. Dohrn,Fathollah Riahi,Susan E. Beekmann,Gary V. Doern +5 more
TL;DR: The penicillin-resistant S. pneumoniae population has changed; most isolates are now closely related to 2 Pneumococcal Molecular Epidemiology Network clones that increased in prevalence from 1999-2000 to 2004-2005.