S
Shyam Ramachandran
Researcher at Roy J. and Lucille A. Carver College of Medicine
Publications - 27
Citations - 2618
Shyam Ramachandran is an academic researcher from Roy J. and Lucille A. Carver College of Medicine. The author has contributed to research in topics: Cystic fibrosis & Cystic fibrosis transmembrane conductance regulator. The author has an hindex of 17, co-authored 24 publications receiving 2326 citations. Previous affiliations of Shyam Ramachandran include Children's Hospital of Philadelphia & University of Iowa.
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Journal ArticleDOI
Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung
Alejandro A. Pezzulo,Xiao Xiao Tang,Mark J. Hoegger,Mahmoud H. Abou Alaiwa,Shyam Ramachandran,Thomas O. Moninger,Phillip H. Karp,Christine L. Wohlford-Lenane,Henk P. Haagsman,Martin van Eijk,Botond Banfi,Alexander R. Horswill,David A. Stoltz,Paul B. McCray,Michael J. Welsh,Joseph Zabner +15 more
TL;DR: It is shown that in newborn wild-type pigs, the thin layer of airway surface liquid (ASL) rapidly kills bacteria in vivo, when removed from the lung and in primary epithelial cultures, which directly link the initial host defence defect to the loss of CFTR, an anion channel that facilitates HCO3− transport.
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Adherens junction protein nectin-4 is the epithelial receptor for measles virus
Michael D. Mühlebach,Mathieu Mateo,Patrick L. Sinn,Steffen Prüfer,Katharina M. Uhlig,Vincent H. J. Leonard,Chanakha K. Navaratnarajah,Marie Frenzke,Xiao X. Wong,Bevan Sawatsky,Shyam Ramachandran,Paul B. McCray,Klaus Cichutek,Veronika von Messling,Marc Lopez,Roberto Cattaneo +15 more
TL;DR: It is suggested that measles virus targets nectin-4 to emerge in the airways, a cellular marker of several types of cancer, which has implications for ongoing measles-virus-based clinical trials of oncolysis.
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Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth
David A. Stoltz,David K. Meyerholz,Alejandro A. Pezzulo,Shyam Ramachandran,Mark P. Rogan,Greg J. Davis,Robert A. Hanfland,Chris Wohlford-Lenane,Cassie L. Dohrn,Jennifer A. Bartlett,George A. Nelson,Eugene H. Chang,Peter J. Taft,Paula S. Ludwig,Mira Estin,Emma E. Hornick,Janice L. Launspach,Melissa Samuel,Tatiana Rokhlina,Philip H. Karp,Lynda S. Ostedgaard,Aliye Uc,Timothy D. Starner,Alexander R. Horswill,Kim A. Brogden,Randall S. Prather,Sandra S. Richter,Joel Shilyansky,Paul B. McCray,Joseph Zabner,Michael J. Welsh +30 more
TL;DR: Findings in cystic fibrosis pigs that survive long enough to develop human-like lung disease are reported, suggesting that impaired bacterial elimination is the pathogenic event that initiates a cascade of inflammation and pathology in CF lungs.
Journal ArticleDOI
Loss of Cystic Fibrosis Transmembrane Conductance Regulator Function Produces Abnormalities in Tracheal Development in Neonatal Pigs and Young Children
David K. Meyerholz,David A. Stoltz,Eman Namati,Shyam Ramachandran,Alejandro A. Pezzulo,Amanda R. Smith,Michael V. Rector,Melissa J. Suter,Simon C. Kao,Geoffrey McLennan,Guillermo J. Tearney,Joseph Zabner,Paul B. McCray,Michael J. Welsh +13 more
TL;DR: The findings in newborn CF pigs and young patients with CF suggest that airway changes begin during fetal life and may contribute to CF pathogenesis and clinical disease during postnatal life.
Journal ArticleDOI
A microRNA network regulates expression and biosynthesis of wild-type and ΔF508 mutant cystic fibrosis transmembrane conductance regulator
Shyam Ramachandran,Philip H. Karp,Peng Jiang,Lynda S. Ostedgaard,Amy E. Walz,John T. Fisher,Shaf Keshavjee,Kim A. Lennox,Ashley M. Jacobi,Scott D. Rose,Mark A. Behlke,Michael J. Welsh,Yi Xing,Paul B. McCray +13 more
TL;DR: In this paper, the miRNA-138 regulates CFTR expression through its interactions with the transcriptional regulatory protein SIN3A and showed that manipulating the miR-138 regulatory network also improved biosynthesis of CFTR-ΔF508 and restored Cl− transport to cystic fibrosis airway epithelia.