M
Mark P. Rogan
Researcher at Roy J. and Lucille A. Carver College of Medicine
Publications - 6
Citations - 1643
Mark P. Rogan is an academic researcher from Roy J. and Lucille A. Carver College of Medicine. The author has contributed to research in topics: Cystic fibrosis & Cystic fibrosis transmembrane conductance regulator. The author has an hindex of 5, co-authored 6 publications receiving 1547 citations. Previous affiliations of Mark P. Rogan include University of Iowa.
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Journal ArticleDOI
Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs.
Christopher S. Rogers,David A. Stoltz,David K. Meyerholz,Lynda S. Ostedgaard,Tatiana Rokhlina,Peter J. Taft,Mark P. Rogan,Alejandro A. Pezzulo,Philip H. Karp,Omar A. Itani,Amanda C. Kabel,Christine L. Wohlford-Lenane,Greg J. Davis,Robert A. Hanfland,Tony L. Smith,Melissa Samuel,David Wax,Clifton N. Murphy,August Rieke,Kristin M. Whitworth,Aliye Uc,Timothy D. Starner,Kim A. Brogden,Joel Shilyansky,Paul B. McCray,Joseph Zabner,Randall S. Prather,Michael J. Welsh +27 more
TL;DR: The pig model may provide opportunities to address persistent questions about CF pathogenesis and accelerate discovery of strategies for prevention and treatment.
Journal ArticleDOI
Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth
David A. Stoltz,David K. Meyerholz,Alejandro A. Pezzulo,Shyam Ramachandran,Mark P. Rogan,Greg J. Davis,Robert A. Hanfland,Chris Wohlford-Lenane,Cassie L. Dohrn,Jennifer A. Bartlett,George A. Nelson,Eugene H. Chang,Peter J. Taft,Paula S. Ludwig,Mira Estin,Emma E. Hornick,Janice L. Launspach,Melissa Samuel,Tatiana Rokhlina,Philip H. Karp,Lynda S. Ostedgaard,Aliye Uc,Timothy D. Starner,Alexander R. Horswill,Kim A. Brogden,Randall S. Prather,Sandra S. Richter,Joel Shilyansky,Paul B. McCray,Joseph Zabner,Michael J. Welsh +30 more
TL;DR: Findings in cystic fibrosis pigs that survive long enough to develop human-like lung disease are reported, suggesting that impaired bacterial elimination is the pathogenic event that initiates a cascade of inflammation and pathology in CF lungs.
Journal ArticleDOI
The ΔF508 Mutation Causes CFTR Misprocessing and Cystic Fibrosis-Like Disease in Pigs
Lynda S. Ostedgaard,David K. Meyerholz,Jeng-Haur Chen,Alejandro A. Pezzulo,Philip H. Karp,Tatiana Rokhlina,Sarah E. Ernst,Robert A. Hanfland,Leah R. Reznikov,Paula S. Ludwig,Mark P. Rogan,Greg J. Davis,Cassie L. Dohrn,Christine L. Wohlford-Lenane,Peter J. Taft,Michael V. Rector,Emma E. Hornick,Boulos Nassar,Melissa Samuel,Yuping Zhang,Sandra S. Richter,Aliye Uc,Joel Shilyansky,Randall S. Prather,Paul B. McCray,Joseph Zabner,Michael J. Welsh,David A. Stoltz +27 more
TL;DR: Pigs may provide a better model of CF because they have more similar anatomy, biochemistry, physiology, size, and genetics to humans than mice, and this new model may help to determine which levels of CFTR are sufficient for function and, therefore, guide future therapeutic strategies.
Journal ArticleDOI
Cystic fibrosis transmembrane conductance regulator intracellular processing, trafficking, and opportunities for mutation-specific treatment.
TL;DR: The structure, function, biosynthetic processing, and intracellular trafficking of CFTR is reviewed and the five classes of mutations and their impact on the CF phenotype are discussed and the therapeutic discussion is focused on the significant progress toward CFTR mutation-specific therapies.
Journal ArticleDOI
Pigs and humans with cystic fibrosis have reduced insulin-like growth factor 1 (IGF1) levels at birth
Mark P. Rogan,Leah R. Reznikov,Alejandro A. Pezzulo,Nicholas D. Gansemer,Melissa Samuel,Randall S. Prather,Joseph Zabner,Douglas C. Fredericks,Paul B. McCray,Michael J. Welsh,David A. Stoltz +10 more
TL;DR: Lower IGF1 levels in newborn pigs and humans indicates that the decrease is not solely a consequence of malnutrition or pulmonary inflammation and that loss of cystic fibrosis transmembrane conductance regulator function has a more direct effect.