E
Emma E. Hornick
Researcher at University of Iowa
Publications - 13
Citations - 1122
Emma E. Hornick is an academic researcher from University of Iowa. The author has contributed to research in topics: Cystic fibrosis & Influenza A virus. The author has an hindex of 11, co-authored 13 publications receiving 988 citations. Previous affiliations of Emma E. Hornick include Cedars-Sinai Medical Center & Roy J. and Lucille A. Carver College of Medicine.
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Journal ArticleDOI
Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth
David A. Stoltz,David K. Meyerholz,Alejandro A. Pezzulo,Shyam Ramachandran,Mark P. Rogan,Greg J. Davis,Robert A. Hanfland,Chris Wohlford-Lenane,Cassie L. Dohrn,Jennifer A. Bartlett,George A. Nelson,Eugene H. Chang,Peter J. Taft,Paula S. Ludwig,Mira Estin,Emma E. Hornick,Janice L. Launspach,Melissa Samuel,Tatiana Rokhlina,Philip H. Karp,Lynda S. Ostedgaard,Aliye Uc,Timothy D. Starner,Alexander R. Horswill,Kim A. Brogden,Randall S. Prather,Sandra S. Richter,Joel Shilyansky,Paul B. McCray,Joseph Zabner,Michael J. Welsh +30 more
TL;DR: Findings in cystic fibrosis pigs that survive long enough to develop human-like lung disease are reported, suggesting that impaired bacterial elimination is the pathogenic event that initiates a cascade of inflammation and pathology in CF lungs.
Journal ArticleDOI
The ΔF508 Mutation Causes CFTR Misprocessing and Cystic Fibrosis-Like Disease in Pigs
Lynda S. Ostedgaard,David K. Meyerholz,Jeng-Haur Chen,Alejandro A. Pezzulo,Philip H. Karp,Tatiana Rokhlina,Sarah E. Ernst,Robert A. Hanfland,Leah R. Reznikov,Paula S. Ludwig,Mark P. Rogan,Greg J. Davis,Cassie L. Dohrn,Christine L. Wohlford-Lenane,Peter J. Taft,Michael V. Rector,Emma E. Hornick,Boulos Nassar,Melissa Samuel,Yuping Zhang,Sandra S. Richter,Aliye Uc,Joel Shilyansky,Randall S. Prather,Paul B. McCray,Joseph Zabner,Michael J. Welsh,David A. Stoltz +27 more
TL;DR: Pigs may provide a better model of CF because they have more similar anatomy, biochemistry, physiology, size, and genetics to humans than mice, and this new model may help to determine which levels of CFTR are sufficient for function and, therefore, guide future therapeutic strategies.
Journal ArticleDOI
Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs
David A. Stoltz,Tatiana Rokhlina,Sarah E. Ernst,Alejandro A. Pezzulo,Lynda S. Ostedgaard,Philip H. Karp,Melissa Samuel,Leah R. Reznikov,Michael V. Rector,Nicholas D. Gansemer,Drake C. Bouzek,Mahmoud M.Abou Alaiwa,Mark J. Hoegger,Paula S. Ludwig,Peter J. Taft,Tanner J. Wallen,Christine L. Wohlford-Lenane,James D. McMenimen,Jeng-Haur Chen,Katrina L. Bogan,Ryan J. Adam,Emma E. Hornick,George A. Nelson,Eric A. Hoffman,Eugene H. Chang,Joseph Zabner,Paul B. McCray,Randall S. Prather,David K. Meyerholz,Michael J. Welsh +29 more
TL;DR: It is shown that expressing CFTR in intestine without pancreatic or hepatic correction is sufficient to rescue meconium ileus, and this model may be of value for understanding CF pathophysiology and testing new preventions and therapies.
Journal ArticleDOI
Glycaemic regulation and insulin secretion are abnormal in cystic fibrosis pigs despite sparing of islet cell mass
Aliye Uc,Alicia K. Olivier,Michelle Griffin,David K. Meyerholz,Jianrong Yao,Maisam Abu-El-Haija,Katherine M. Buchanan,Oriana G. Vanegas Calderón,Marwa Abu-El-Haija,Alejandro A. Pezzulo,Leah R. Reznikov,Mark J. Hoegger,Michael V. Rector,Lynda S. Ostedgaard,Peter J. Taft,Nicholas D. Gansemer,Paula S. Ludwig,Emma E. Hornick,David A. Stoltz,Katie Larson Ode,Michael J. Welsh,Michael J. Welsh,John F. Engelhardt,Andrew W. Norris,Andrew W. Norris +24 more
TL;DR: Glycaemic abnormalities and insulin secretion defects were present in newborn CF pigs and spontaneous hyperglycaemia developed over time, suggesting that functional islet abnormalities, independent of structural islet loss, contribute to the early pathogenesis of CFRD.
Journal ArticleDOI
NLRC4 suppresses melanoma tumor progression independently of inflammasome activation
Ann M. Janowski,Ann M. Janowski,Oscar R. Colegio,Emma E. Hornick,Emma E. Hornick,Jennifer M. McNiff,Matthew D. Martin,Vladimir P. Badovinac,Lyse A. Norian,Weizhou Zhang,Suzanne L. Cassel,Suzanne L. Cassel,Fayyaz S. Sutterwala,Fayyaz S. Sutterwala +13 more
TL;DR: A syngeneic subcutaneous murine model of B16F10 melanoma and examination of human primary melanomas revealed the extensive presence of NLRC4+ tumor-associated macrophages, supporting the concept thatNLRC4 expression controls tumor growth.