Caterina Brandmayr

TL;DR: Protein pull-down experiments in combination with peptide tracing identifies hmU as a base that influences binding of chromatin remodeling proteins and transcription factors, suggesting that hm U has a specific function in stem cells besides triggering DNA repair.

TL;DR: DNA and RNA contain, next to the four canonical nucleobases, a number of modified nucleosides that extend their chemical information content, which is clearly linked to increased chemical diversity.

TL;DR: The synthesis of the triphosphates of 5-hydroxymethyl, 5-formyl-, and 5-carboxycytidine and the incorporation of these building blocks into long DNA fragments using the polymerase chain reaction (PCR) are reported.

TL;DR: Quantification of modified tRNA nucleobases in different murine and porcine tissues reveals a tissue-specific overall modification content, suggesting a direct link between tRNA modification levels and tissue- specific translational efficiency.