M
Markus Müller
Researcher at Ludwig Maximilian University of Munich
Publications - 59
Citations - 5185
Markus Müller is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Transplantation & Transfer RNA. The author has an hindex of 27, co-authored 58 publications receiving 4603 citations. Previous affiliations of Markus Müller include Protein Sciences & Center for Integrated Protein Science Munich.
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Journal ArticleDOI
Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives
Cornelia G. Spruijt,Felix Gnerlich,Arne H. Smits,Toni Pfaffeneder,Pascal W.T.C. Jansen,Christina Bauer,Martin Münzel,Mirko Wagner,Markus Müller,Fariha Khan,Fariha Khan,H. Christian Eberl,Anneloes Mensinga,Arie B. Brinkman,Konstantin Lephikov,Udo Müller,Jörn Walter,Rolf Boelens,Hugo van Ingen,Heinrich Leonhardt,Thomas Carell,Michiel Vermeulen +21 more
TL;DR: Oxidized derivatives of mC recruit distinct transcription regulators as well as a large number of DNA repair proteins in mouse ES cells, implicating the DNA damage response as a major player in active DNA demethylation.
Journal ArticleDOI
Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates
Daniel Globisch,Martin Münzel,Markus Müller,Stylianos Michalakis,Mirko Wagner,Susanne Koch,Tobias Brückl,Martin Biel,Thomas Carell +8 more
TL;DR: The data suggest that an active oxidative mC demethylation pathway is unlikely to occur and show that hmC is present in all tissues and cell types with highest concentrations in neuronal cells of the CNS.
Journal ArticleDOI
The Discovery of 5-Formylcytosine in Embryonic Stem Cell DNA†
Toni Pfaffeneder,Benjamin Hackner,Matthias Truß,Martin Münzel,Markus Müller,Christian A. Deiml,Christian Hagemeier,Thomas Carell +7 more
TL;DR: Recent data suggest that active demethylation in postdevelopmental phases may proceed through deamination of hmC to give 5-hydroxymethyluridine (hmU), which is then removed from the genome with the help of the base excision repair (BER) system.
Journal ArticleDOI
N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis.
Raghu Ram Edupuganti,Simon Geiger,Rik G.H. Lindeboom,Hailing Shi,Phillip J. Hsu,Zhike Lu,Shuang-Yin Wang,Marijke P. Baltissen,Pascal W.T.C. Jansen,Martin Rossa,Markus Müller,Hendrik G. Stunnenberg,Chuan He,Thomas Carell,Michiel Vermeulen +14 more
TL;DR: Comprehensive and systematic mass-spectrometry-based screening of m6A interactors in various cell types and sequence contexts identifies G3BP1 as a protein that is repelled by m 6A and positively regulates mRNA stability in an m6a-regulated manner, thus revealing a connection between an mRNA modification and an autism spectrum disorder.