C
Catherine Bryant
Researcher at University of Southampton
Publications - 12
Citations - 1243
Catherine Bryant is an academic researcher from University of Southampton. The author has contributed to research in topics: Histone H3 & Myeloid. The author has an hindex of 6, co-authored 8 publications receiving 1150 citations. Previous affiliations of Catherine Bryant include Salisbury NHS Foundation Trust & Salisbury University.
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Journal ArticleDOI
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
Thomas Ernst,Andrew Chase,Andrew Chase,Joannah Score,Joannah Score,Claire Hidalgo-Curtis,Claire Hidalgo-Curtis,Catherine Bryant,Catherine Bryant,Amy V. Jones,Amy V. Jones,Katherine Waghorn,Katherine Waghorn,Katerina Zoi,Fiona M. Ross,Fiona M. Ross,Andreas Reiter,Andreas Hochhaus,Hans G. Drexler,Andrew S Duncombe,Francisco Cervantes,David Oscier,Jacqueline Boultwood,Francis H. Grand,Francis H. Grand,Nicholas C.P. Cross,Nicholas C.P. Cross +26 more
TL;DR: In this article, the finding of homozygous EZH2 mutations in 9 of 12 individuals with 7q acquired uniparental disomy was described, and the mutations resulted in premature chain termination or direct abrogation of histone methyltransferase activity.
Journal ArticleDOI
Ponatinib as targeted therapy for FGFR1 fusions associated with the 8p11 myeloproliferative syndrome
TL;DR: Ponatinib shows considerable promise for the treatment of patients with 8p11 myeloproliferative syndrome as inhibition induced apoptosis and reduced phosphorylation of the FGFR1 fusion proteins and substrates.
Journal ArticleDOI
Laser-patterned paper-based sensors for rapid point-of-care detection and antibiotic-resistance testing of bacterial infections.
Peijun He,Ioannis Katis,Anto J.U. Kumar,Catherine Bryant,C. W. Keevil,Bhaskar K. Somani,Nitin Mahobia,Robert W. Eason,Collin Sones +8 more
TL;DR: The results indicate the suitability of the integrated paper devices for timely identification of bacterial infections at the point-of-care and their usefulness in providing a hugely beneficial pathway for accurate antibiotic prescribing and thus a novel route to tackling the global challenge of AMR.
Journal ArticleDOI
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements
Andrew Chase,Catherine Bryant,Catherine Bryant,Joannah Score,Joannah Score,Claudia Haferlach,Vera Grossmann,Juliana Schwaab,Wolf-Karsten Hofmann,Andreas Reiter,Nicholas C.P. Cross,Nicholas C.P. Cross +11 more
TL;DR: Evidence is provided that ruxolitinib is a promising therapy for treatment of patients with JAK2 fusion genes and reduced colony growth was seen for all patients in ruxolinib-treated cultures compared with healthy controls.
Journal ArticleDOI
Profound parental bias associated with chromosome 14 acquired uniparental disomy indicates targeting of an imprinted locus
Andrew Chase,Andrew Chase,William T. M. Leung,William T. M. Leung,William J. Tapper,Amy V. Jones,Amy V. Jones,Laurent Knoops,Chiara Rasi,Lars Forsberg,Paola Guglielmelli,Katerina Zoi,Vickie Hall,Vickie Hall,Laura Chiecchio,Laura Eder-Azanza,Catherine Bryant,Catherine Bryant,Lars Lannfelt,Louise E Docherty,Louise E Docherty,Helen E. White,Helen E. White,Joannah Score,Joannah Score,Deborah J G Mackay,Deborah J G Mackay,Alessandro M. Vannucchi,Jan P. Dumanski,Nicholas C.P. Cross,Nicholas C.P. Cross +30 more
TL;DR: It is concluded that aUPD14q is a recurrent abnormality that targets an imprinted locus and may promote clonal haemopoiesis either as an initiating event or as a secondary change.