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Catherine L. Gebhart
Researcher at University of Nebraska Medical Center
Publications - 20
Citations - 1498
Catherine L. Gebhart is an academic researcher from University of Nebraska Medical Center. The author has contributed to research in topics: Gene delivery & Immune system. The author has an hindex of 12, co-authored 18 publications receiving 1452 citations. Previous affiliations of Catherine L. Gebhart include Nebraska Medical Center.
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Journal ArticleDOI
Evaluation of polyplexes as gene transfer agents.
TL;DR: Good potential of structurally diverse polyplex systems as transfection reagents with relatively low cytotoxicity is demonstrated.
Journal ArticleDOI
Evaluation of polyether-polyethyleneimine graft copolymers as gene transfer agents.
H. K. Nguyen,Pierre Lemieux,Serguei V. Vinogradov,Catherine L. Gebhart,N Guérin,G Paradis,Tatiana K. Bronich,V Y Alakhov,Alexander V. Kabanov +8 more
TL;DR: Compared to 1,2-bis(oleoyloxy)-(trimethylammonio) propane:cholesterol (DOTAP:Chol) and PEI (25 kDa) transfection systems, the P123-PEI system reveals a more uniform distribution of gene expression between these organs, allowing a significant improvement of geneexpression in liver.
Journal ArticleDOI
Design and formulation of polyplexes based on pluronic-polyethyleneimine conjugates for gene transfer
Catherine L. Gebhart,Srikanth Sriadibhatla,Sergey V. Vinogradov,Pierre Lemieux,V Y Alakhov,Alexander V. Kabanov +5 more
TL;DR: Though this system displays several characteristics thought desirable of a nonviral gene delivery system, these studies did discriminate a potential limitation of this system for in vivo applications, namely, the insufficient level of protection of plasmid DNA from nuclease degradation.
Journal ArticleDOI
Block and graft copolymers and NanoGel copolymer networks for DNA delivery into cell.
Pierre Lemieux,Serguei V. Vinogradov,Catherine L. Gebhart,N Guérin,G Paradis,H. K. Nguyen,B. Ochietti,Yulia G. Suzdaltseva,E V Bartakova,Tatiana K. Bronich,Yves St-Pierre,V Y Alakhov,Alexander V. Kabanov +12 more
TL;DR: The approaches using polycations for gene delivery for the design of gene transfer complexes that exhibit a very broad range of physicochemical and biological properties are essential for design of a new generation of more effective non-viral gene delivery systems.
Journal ArticleDOI
Transcriptional Activation of Gene Expression by Pluronic Block Copolymers in Stably and Transiently Transfected Cells
Srikanth Sriadibhatla,Zhihui Yang,Catherine L. Gebhart,Valery Yu Alakhov,Alexander V. Kabanov +4 more
TL;DR: Results indicate that Pluronics can increase the transcription of genes, in part, through the activation of selected stress signaling pathways through the Activation of the inflammation signaling pathway in myoblast cells by Pluronic.