C
Catherine Lavazec
Researcher at Paris Descartes University
Publications - 34
Citations - 1555
Catherine Lavazec is an academic researcher from Paris Descartes University. The author has contributed to research in topics: Plasmodium falciparum & Gametocyte. The author has an hindex of 20, co-authored 28 publications receiving 1383 citations. Previous affiliations of Catherine Lavazec include Centre national de la recherche scientifique & Pasteur Institute.
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Potent Antiplasmodial Derivatives of Dextromethorphan Reveal the Ent-Morphinan Pharmacophore of Tazopsine-Type Alkaloids
A. Keita,Jean-François Franetich,Maëlle Carraz,Loise Valentin,Mallaury Bordessoules,Ludivine Baron,Pierre-Henri Bigeard,Florian Dupuy,Valentine Geay,Maurel Tefit,Véronique Sarrasin,Sylvie Michel,Catherine Lavazec,Sandrine Houzé,Dominique Mazier,Valérie Soulard,François-Hugues Porée,Romain Duval +17 more
TL;DR: It is found that the antitussive drug dextromethorphan (DXM) 3, although lacking the complex pattern of stereospecific functionalization of the natural hit, was harboring significant antiplasmodial activity in vitro despite suboptimal prophylactic activity in a murine model of malaria, precluding its direct repurposing against the disease.
Posted ContentDOI
Potent Antiplasmodial Derivatives of the Antitussive Drug Dextromethorphan Reveal the Ent-Morphinan Pharmacophore of Tazopsine-Type Alkaloids
A. Keita,Jean-François Franetich,Maëlle Carraz,Loise Valentin,Ludivine Baron,Pierre-Henri Bigeard,Florian Dupuy,Valentine Geay,Maurel Tefit,Véronique Sarrasin,Sylvie Michel,Catherine Lavazec,Sandrine Houzé,Dominique Mazier,Valérie Soulard,François-Hugues Porée,Romain Duval +16 more
TL;DR: It is found that the antitussive drug dextromethorphan (DXM) 3, although lacking the complex pattern of stereospecific functionalization of the natural hit, was harboring significant antiplasmodial activity in vitro despite suboptimal prophylactic activity in a murine model of malaria, which precluded its direct repurposing against malaria.
Journal ArticleDOI
The Phosphodiesterase Inhibitor Tadalafil Promotes Splenic Retention of Plasmodium falciparum Gametocytes in Humanized Mice
Daniela Barbieri,Lina Andrea Gómez,Ludivine Royer,Florian Dupuy,Jean-François Franetich,Maurel Tefit,Marie-Esther N’Dri,Dominique Mazier,Olivier Silvie,Alicia Moreno-Sabater,Catherine Lavazec +10 more
TL;DR: In vivo results validate that tadalafil is a novel drug lead potentially capable of blocking malaria parasite transmission by targeting GIE mechanical properties.
Journal ArticleDOI
Phosphodiesterase delta governs the mechanical properties of erythrocytes infected with Plasmodium falciparum gametocytes.
Marie-Esther N’Dri,Tatyana Almeida Tavella,Ludivine Royer,Florian Dupuy,Laurianne Bedault,Frédérique Verdier,Catherine Lavazec +6 more
TL;DR: In this paper , the authors characterized the P. falciparum phosphodiesterase delta (PfPDEδ) and investigated its role in the cAMP signaling-mediated regulation of gametocyte-infected erythrocyte mechanical properties.