C
Catherine Lavazec
Researcher at Paris Descartes University
Publications - 34
Citations - 1555
Catherine Lavazec is an academic researcher from Paris Descartes University. The author has contributed to research in topics: Plasmodium falciparum & Gametocyte. The author has an hindex of 20, co-authored 28 publications receiving 1383 citations. Previous affiliations of Catherine Lavazec include Centre national de la recherche scientifique & Pasteur Institute.
Papers
More filters
Journal ArticleDOI
Artesunate Tolerance in Transgenic Plasmodium falciparum Parasites Overexpressing a Tryptophan-Rich Protein
Guillaume Deplaine,Guillaume Deplaine,Guillaume Deplaine,Catherine Lavazec,Emmanuel Bischoff,Emmanuel Bischoff,Onguma Natalang,Onguma Natalang,Sylvie Perrot,Sylvie Perrot,Micheline Guillotte-Blisnick,Micheline Guillotte-Blisnick,Jean-Yves Coppée,Bruno Pradines,Odile Mercereau-Puijalon,Odile Mercereau-Puijalon,Peter H. David,Peter H. David +17 more
TL;DR: This is the first report of genetically manipulated parasites displaying a stable and reproducible decreased susceptibility to artesunate, providing new possibilities to investigate the parasite response to artemisinins.
Journal ArticleDOI
An Evolution-Based Screen for Genetic Differentiation between Anopheles Sister Taxa Enriches for Detection of Functional Immune Factors
Christian Mitri,Emmanuel Bischoff,Emmanuel Bischoff,Eizo Takashima,Eizo Takashima,Marni Williams,Karin Eiglmeier,Karin Eiglmeier,Adrien Pain,Adrien Pain,Wamdaogo M. Guelbeogo,Awa Gneme,Emma Brito-Fravallo,Emma Brito-Fravallo,Inge Holm,Inge Holm,Catherine Lavazec,Catherine Lavazec,N’Fale Sagnon,Richard H. G. Baxter,Michelle M. Riehle,Kenneth D. Vernick,Kenneth D. Vernick,Kenneth D. Vernick +23 more
TL;DR: An evolution-based screen can efficiently prioritize candidate genes for labor-intensive downstream functional testing, and safely allow the elimination of genes not meeting the screen criteria, and find that most malaria-protective immune factors display phenotypes for either human or rodent malaria, with broad specificity a rarity.
Journal ArticleDOI
Erythrocyte membrane makeover by Plasmodium falciparum gametocytes
Gaëlle Neveu,Catherine Lavazec +1 more
TL;DR: The mechanisms developed by gametocytes to remodel their host cell and the functional relevance of these modifications are discussed.
Journal ArticleDOI
Diverged Alleles of the Anopheles gambiae Leucine-Rich Repeat Gene APL1A Display Distinct Protective Profiles against Plasmodium falciparum
Inge Holm,Catherine Lavazec,Thierry Garnier,Christian Mitri,Michelle M. Riehle,Emmanuel Bischoff,Emma Brito-Fravallo,Eizo Takashima,Isabelle Thiery,Agnès Zettor,Stéphane Petres,Catherine Bourgouin,Kenneth D. Vernick,Kenneth D. Vernick,Karin Eiglmeier +14 more
TL;DR: The structure of the APL1 locus is exhaustively characterized and it is shown that three structurally differentAPL1A alleles segregate in the Ngousso colony, suggesting that APL 1A genetic variation could be a factor underlying natural heterogeneity of vector susceptibility to P. falciparum.
Journal ArticleDOI
Characterization of an A-kinase anchoring protein-like suggests an alternative way of PKA anchoring in Plasmodium falciparum
Kossiwa Bandje,Bernina Naissant,Pascal Bigey,Pascal Bigey,Murielle Lohezic,Marlène Vayssières,Marlène Vayssières,Magali Blaud,Magali Blaud,Laetitia Kermasson,Jose-Juan Lopez-Rubio,Gordon Langsley,Catherine Lavazec,Philippe Deloron,Anais Merckx +14 more
TL;DR: PfAKAL is the first AKAP-like protein in P. falciparum to be identified, and shares 23 % sequence identity with the central domain of human AKAP18δ, and binds nucleotides such as AMP and cAMP, suggesting that this protein may be involved in the AMP-activated protein kinase (AMPK) pathway, or associated with phosphodiesterase activities.