C
Catherine Lavazec
Researcher at Paris Descartes University
Publications - 34
Citations - 1555
Catherine Lavazec is an academic researcher from Paris Descartes University. The author has contributed to research in topics: Plasmodium falciparum & Gametocyte. The author has an hindex of 20, co-authored 28 publications receiving 1383 citations. Previous affiliations of Catherine Lavazec include Centre national de la recherche scientifique & Pasteur Institute.
Papers
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Journal ArticleDOI
cpbAg1 encodes an active carboxypeptidase B expressed in the midgut of Anopheles gambiae.
TL;DR: The characterization of cpbAg1, which codes for the first zinc‐carboxypeptidase B identified in An.
Journal ArticleDOI
A humanized mouse model for sequestration of Plasmodium falciparum sexual stages and in vivo evaluation of gametocytidal drugs
Yoann Duffier,Audrey Lorthiois,Pau Cisteró,Florian Dupuy,Grégory Jouvion,Laurence Fiette,Dominique Mazier,Alfredo Mayor,Catherine Lavazec,Alicia Moreno Sabater +9 more
TL;DR: It is shown that chemically immune-modulated NSG mice grafted with human erythrocytes support complete sexual development of P. falciparum parasites and generate high gametocytemia, and provides the missing link between current in vitro assays and Phase I trials in humans for testing new malariagametocytidal drugs.
Book ChapterDOI
Microsphiltration: A Microsphere Matrix to Explore Erythrocyte Deformability
Catherine Lavazec,Guillaume Deplaine,Innocent Safeukui,Sylvie Perrot,Geneviève Milon,Odile Mercereau-Puijalon,Peter H. David,Pierre Buffet +7 more
TL;DR: A new method, called microsphiltration, based on filtration of erythrocytes through a mixture of metal microspheres that mimic the geometry of inter-endothelial splenic slits is developed, which allows for molecular analyses of subpopulations with distinct mechanical phenotypes.
Journal ArticleDOI
Splenic Retention of Plasmodium falciparum Gametocytes To Block the Transmission of Malaria
Julien Duez,Julien Duez,John P. Holleran,Papa Alioune Ndour,Sasdekumar Loganathan,Pascal Amireault,Olivier Français,Wassim El Nemer,Bruno Le Pioufle,Inês F. Amado,Sylvie Garcia,Nathalie Chartrel,Caroline Le Van Kim,Catherine Lavazec,Vicky M. Avery,Pierre Buffet +15 more
TL;DR: Mature gametocytes exposed to calyculin accumulated in microfluidic chips and were cleared from the circulation of macrophage-depleted mice as rapidly as heat-stiffened erythrocytes, thus confirming results obtained using the microsphiltration assay.
Journal ArticleDOI
Plasmodium falciparum gametocyte-infected erythrocytes do not adhere to human primary erythroblasts.
Gaëlle Neveu,Florian Dupuy,Meriem Ladli,Daniela Barbieri,Bernina Naissant,Cyrielle Richard,Rafael M. Martins,Jose-Juan Lopez-Rubio,Anna Bachmann,Frédérique Verdier,Catherine Lavazec +10 more
TL;DR: Investigation of gametocyte-infected erythrocytes infected with P. falciparum asexual stages and clonal lines and transgenic parasites used to determine whether adhesion may be dependent on binding of STEVOR proteins to Glycophorin C on the surface of erythroid cells indicates that GIE overexpressing STevOR do not specifically adhere to ery throatblasts.