C
Cecile A. Donohue
Researcher at City of Hope National Medical Center
Publications - 6
Citations - 226
Cecile A. Donohue is an academic researcher from City of Hope National Medical Center. The author has contributed to research in topics: Gene & Genetic enhancement. The author has an hindex of 5, co-authored 5 publications receiving 197 citations. Previous affiliations of Cecile A. Donohue include Beckman Research Institute.
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Journal ArticleDOI
CD30 Downregulation, MMAE Resistance, and MDR1 Upregulation Are All Associated with Resistance to Brentuximab Vedotin
Robert T. Chen,Jessie Hou,Edward M. Newman,Young L. Kim,Cecile A. Donohue,Xueli Liu,Sandra H. Thomas,Stephen J. Forman,Susan E. Kane +8 more
TL;DR: MMAE resistance and MDR1 expression are possible modes of BV resistance for Hodgkin lymphoma both in vitro and in patients.
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Iron chelators induce autophagic cell death in multiple myeloma cells
Vinod Pullarkat,Zhuo Meng,Cecile A. Donohue,Vicky Yamamoto,Sarah Tomassetti,Ravi Bhatia,Amrita Krishnan,Stephen J. Forman,Timothy W. Synold +8 more
TL;DR: It is demonstrated that autophagy induced by iron deprivation is the dominant mechanism that mediates the cytotoxicity of iron chelators in multiple myeloma.
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Pancreatic cancer in vitro toxicity mediated by Chinese herbs SPES and PC-SPES: implications for monotherapy and combination treatment
TL;DR: Both SPES and PC-SPES exhibited significant toxicity in pancreatic cancer cells, mediated via induction of apoptosis, and should be evaluated for their in vivo and clinical therapeutic utility as monotherapy agents against Pancic cancer.
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Chemosensitization by fibroblast growth factor-2 is not dependent upon proliferation, S-phase accumulation, or p53 status
Aaron B. Coleman,Marianne Z. Metz,Cecile A. Donohue,Cecile A. Donohue,Roderich E. Schwarz,Susan E. Kane +5 more
TL;DR: FGF-2 can sensitize NIH 3T3 mouse fibroblasts to the cytotoxic and apoptotic effects of cisplatin and was most effective with the platinum compounds, suggesting that this activity may be specific to particular mechanisms of drug action.
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MDR1 bicistronic vectors: analysis of selection stringency, amplified gene expression, and vector stability in cell lines.
Susan E. Kane,Linda Matsumoto,Marianne Z. Metz,Cecile A. Donohue,Robert G. Lingeman,Sharon W Lin,James H. Doroshow +6 more
TL;DR: In this paper, a bicistronic vector encoding MDR1 and neo genes linked through an internal ribosome entry site was transferred into NIH 3T3 mouse fibroblasts and K562 human leukemia cells.