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James H. Doroshow

Researcher at National Institutes of Health

Publications -  614
Citations -  30425

James H. Doroshow is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 81, co-authored 549 publications receiving 26773 citations. Previous affiliations of James H. Doroshow include St. Joseph Hospital & City of Hope National Medical Center.

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Journal ArticleDOI

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

Junko Murai, +8 more
- 01 Nov 2012 - 
TL;DR: This study shows that PARP inhibitors trap the PARP1 and PARP2 enzymes at damaged DNA, providing a new mechanistic foundation for the rational application ofPARP inhibitors in cancer therapy.
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Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rate by the advanced colorectal cancer meta-analysis project

Pascal Piedbois, +9 more
- 01 Jan 1992 - 
TL;DR: Tumor response should not be considered a valid surrogate end point for survival in patients with advanced colorectal cancer in future trials, according to a meta-analysis performed on nine randomized clinical trials.
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Enzymatic Defenses of the Mouse Heart Against Reactive Oxygen Metabolites: ALTERATIONS PRODUCED BY DOXORUBICIN

James H. Doroshow, +2 more
- 01 Jan 1980 - 
TL;DR: Results suggest that the major pathway in cardiac tissue for detoxification of reactive oxygen metabolites is via the concerted action of superoxide dismutase and selenium-dependent glutathione peroxidase, leaving the heart with limited mechanisms for disposing of hydrogen peroxide or lipid peroxides.
Journal Article

Effect of Anthracycline Antibiotics on Oxygen Radical Formation in Rat Heart

James H. Doroshow
- 01 Feb 1983 - 
TL;DR: In this paper, the effect of the anthracycline antitumor agents on reactive oxygen metabolism in rat heart was examined, and it was shown that free radical formation by the antimalarial agents may damage the heart by exceeding the oxygen radical detoxifying capacity of cardiac mitochondria and sarcoplasmic reticulum.
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CellMiner: a web-based suite of genomic and pharmacologic tools to explore transcript and drug patterns in the NCI-60 cell line set

William C. Reinhold, +8 more
- 15 Jul 2012 - 
TL;DR: A CellMiner web application is introduced designed to improve the use of the extensive NCI-60 cell line database for discovery by creating web-based processes that are rapid, flexible, and readily applied by users without bioinformatics expertise.