Showing papers in "Cancer Letters in 2003"

TL;DR: The insulin-like growth factor (IGF) family of ligands, binding proteins and receptors is an important growth factor system involved in both the development of the organism and the maintenance of normal function of many cells of the body.

TL;DR: Recent knowledge about membrane-type 1 matrix metalloproteinase (MT1-MMP) which is expressed on cancer cell surface as an invasion-promoting proteinase is summarized to give insight to develop new methods for treating invasive cancer patients.

TL;DR: Tart cherry anthocyanins and cyanidin may reduce the risk of colon cancer and inhibit intestinal tumor development in Apc(Min) mice and growth of human colon cancer cell lines.

TL;DR: The cytotoxic retinoid 4-HPR achieved multi-log cell kills in neuroblastoma cell lines resistant to ATRA and 13-cis-RA, and a pediatric phase I trial has shown it to be well tolerated.

TL;DR: It is shown that cinnamaldehyde is a potent inducer of apoptosis and that it transduces the apoptotic signal via ROS generation, thereby inducing mitochondrial permeability transition (MPT) and cytochrome c release to the cytosol.

TL;DR: Bioassay-guided purification of an extract of Cucurbita andreana fruits yielded cucurbitacins B (1), D (2), E (3), and I (4), which were evaluated for their inhibitory effects on the growth of human colon, breast, lung, and central nervous system cancer cell lines, cyclooxygenase-1 and COX-2 enzymes and on lipid peroxidation.

TL;DR: The various methods under investigation to directly or indirectly measure tissue oxygen in vivo are discussed and the advantages and disadvantages of each are considered.

TL;DR: The recently published study provided the first evidence that COX-2 is overexpressed in human prostate adenocarcinoma, and an exciting corollary to this ongoing work is that selective COx-2 inhibitors may exhibit chemopreventive and even chemotherapeutic effects against prostate carcinogenesis in humans.

TL;DR: It is hypothesized here that inherited abnormalities of telomerase activity and other aspects of telomere maintenance may contribute to cancer and ageing.

TL;DR: The reduced activity of JNK1, in spite of its overexpression, appears to reflect increased MKP activity associated with primary breast cancer, and suppression ofMKP activity therapeutically may enable the expression of the pro-apoptotic signals from JNK in malignant cells.

TL;DR: In situ detection of hTERT mRNA or protein will facilitate the reliability of telomerase as a tumor marker, but careful attention should be paid to the false negative results due to the instability of this enzyme or h TERT mRNA and the existence of polymerase chain reaction inhibitors.

TL;DR: The results suggest that common alterations in single DNA repair genes are not major determinants of lung cancer susceptibility among smokers.

TL;DR: Accumulating evidence indicates that CpG island hypermethylation is an early event in cancer development and, in some cases, may precede the neoplastic process.

TL;DR: Although larger studies are needed to validate the study results, the data suggest that amino acid substitution variants of XRCC1 and XR CC3 genes may contribute to breast cancer susceptibility.

TL;DR: If p53 inactivation occurs frequently in relapsed tumours it may be appropriate to include p53 independent therapies in the initial management of high-risk neuroblastoma.

TL;DR: This short review focuses on those twelve metastasis suppressor genes for which functional data exist and outlines newly identified genes that bear promising traits of having metastasis suppressing activity, but for whichfunctional data have not been completed.

TL;DR: Results point at a dualistic influence of quercetin on cell proliferation that may affect present views on its supposed beneficial anti-proliferative effect.

TL;DR: Results indicate that activation of the JAK/Stat3 signaling pathway plays an important role in the progression of pancreatic cancer and that blockade of JAK /Stat3 signals may provide a novel therapeutic strategy for pancreaticcancer.

TL;DR: The results suggest that in vivo studies of the effect of resveratrol on melanoma are warranted and that this plant polyphenol might have effectiveness as either a therapeutic or chemopreventive agent against melanoma.

TL;DR: These triterpenoids inhibited the growth and induced apoptosis of K562, an erythroleukemia cell line and inhibited the proliferation of Lucena 1, a vincristine-resistant derivative of K582 that displays several multidrug resistance (MDR) characteristics.

TL;DR: The results of this study show that the MTT-reducing activity can be increased by the polyphenolic antioxidant resveratrol without a corresponding increase in the number of living cells and that this occurs at a concentration range of the antioxidant which is not sufficient to induce apoptosis but suffices to slow down cell growth.

TL;DR: The data suggest that mutational inactivation of the DNMT1 gene that potentially causes a genome-wide alteration of DNA methylation status may be a rare event during human carcinogenesis.

TL;DR: The isolated peptides are functional outside of the context of the phage and multimerization of the peptide increases its affinity for its given cell type, thus expanding their utility in clinical situations.

TL;DR: The tBax(29) would be valuable for the treatment of tumors with high levels of Bcl-x(L) as well as the understanding of Bax-mediated apoptotic processes.

TL;DR: Two natural sweeteners isolated from the fruits of Momordica grosvenori exhibited strong inhibitory effect on the primary screening test indicated by the induction of Epstein-Barr virus early antigen by a tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA).

TL;DR: Ginger-specific constituents other than curcuminoids are potential anticancer agents, and galanals A and B, isolated from the flower buds of a Japanese ginger, myoga, showed the most potent cytotoxic effect.

TL;DR: Gene methylation and K-ras mutations were examined in tumor and paired serum DNA of 50 resected non-small-cell lung cancer patients and correlated significantly with survival, but no correlation was found with survival.

TL;DR: The results suggest that ACA, ZER, and BITC suppress iNOS/COX-2 gene expression mainly by attenuating IκB degradation, while other chemopreventive agents use alternative pathway(s) to suppress the expression of proinflammatory genes.

TL;DR: The findings suggest that the presence of L1 might contribute to tumor progression by promoting cell adhesion and migration.

TL;DR: There is a higher incidence of I-type cells in tumors that progress, consistent with the high malignant potential of this cell type in vitro, and this is an important prerequisite to the development of more effective therapies for this often fatal disease.