C
Cécile Sicard-Roselli
Researcher at Université Paris-Saclay
Publications - 41
Citations - 1058
Cécile Sicard-Roselli is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Radical & Colloidal gold. The author has an hindex of 17, co-authored 37 publications receiving 908 citations. Previous affiliations of Cécile Sicard-Roselli include University of Paris & Centre national de la recherche scientifique.
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Journal ArticleDOI
Parameters governing gold nanoparticle X-ray radiosensitization of DNA in solution
TL;DR: The most efficient parameters are found to be large-sized GNP, high molar concentration and 50-keV photons, which could potentially result in a dose enhancement factor of 6.8 to 70 keV.
Journal ArticleDOI
A New Mechanism for Hydroxyl Radical Production in Irradiated Nanoparticle Solutions
Cécile Sicard-Roselli,Emilie Brun,Manon Gilles,G. Baldacchino,Colin Kelsey,Harold McQuaid,Chris Polin,Nathan Wardlow,Frederick Currell +8 more
TL;DR: The absolute yield of hydroxyl radicals per unit of deposited X-ray energy is determined for the first time for irradiated aqueous solutions containing metal nanoparticles based on a "reference" protocol.
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Damage induced to DNA by low-energy (0-30 eV) electrons under vacuum and atmospheric conditions.
TL;DR: It is shown that it is possible to obtain data on DNA damage induced by low-energy (0-30 eV) electrons under atmospheric conditions and the differences in damage yields recorded with the gold and glass substrates is essentially attributed to the interaction of low- energy electrons with DNA under vacuum and hydrated conditions.
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Energy Dependence of Gold Nanoparticle Radiosensitization in Plasmid DNA
Stephen J. McMahon,Wendy B. Hyland,Emilie Brun,Karl T. Butterworth,Jonathan A. Coulter,Thierry Douki,David G. Hirst,Suneil Jain,Anthony Kavanagh,Zeljka Krpetic,Marcus H. Mendenhall,Mark F. Muir,Kevin M. Prise,Herwig Requardt,Léon Sanche,Léon Sanche,Giuseppe Schettino,Frederick Currell,Cécile Sicard-Roselli +18 more
TL;DR: In this paper, the results of three sets of experiments that indepen-dently mapped out the energy dependence of the radiosensitiz-ing effects of GNPs on plasmid DNA suspended in water.
Journal ArticleDOI
Gold nanoparticles functionalization notably decreases radiosensitization through hydroxyl radical production under ionizing radiation
TL;DR: It is suggested that to keep GNP efficient for radiotherapy, a wispy coating is required as GNP translation from fundamental research to applied medicine requires their functionalization to increase blood circulation time and specific cancerous cells addressing.