G
Giuseppe Schettino
Researcher at National Physical Laboratory
Publications - 119
Citations - 4736
Giuseppe Schettino is an academic researcher from National Physical Laboratory. The author has contributed to research in topics: Microbeam & Relative biological effectiveness. The author has an hindex of 32, co-authored 109 publications receiving 4059 citations. Previous affiliations of Giuseppe Schettino include Queen's University Belfast & University of Surrey.
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Journal ArticleDOI
Biological consequences of nanoscale energy deposition near irradiated heavy atom nanoparticles
Stephen J. McMahon,Wendy B. Hyland,Mark F. Muir,Jonathan A. Coulter,Suneil Jain,Suneil Jain,Karl T. Butterworth,Giuseppe Schettino,Glenn R. Dickson,Alan R. Hounsell,Alan R. Hounsell,Joe M. O'Sullivan,Joe M. O'Sullivan,Kevin M. Prise,David G. Hirst,Frederick Currell +15 more
TL;DR: The first calculations which take into account the structure of energy deposition in the nanoscale vicinity of GNPs and relate this to biological outcomes are presented, and show for the first time good agreement with experimentally observed cell killing by the combination of X-rays and GNPs.
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New insights on cell death from radiation exposure
TL;DR: New insights into mechanisms of these responses coupled with technological advances in targeting of cells in experimental systems with microbeams have led to a reassessment of the model of how cells are killed by ionising radiation.
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Evaluation of cytotoxicity and radiation enhancement using 1.9 nm gold particles: potential application for cancer therapy
Karl T. Butterworth,Jonathan A. Coulter,Suneil Jain,J. Forker,Stephen J. McMahon,Giuseppe Schettino,Kevin M. Prise,Frederick Currell,David G. Hirst +8 more
TL;DR: This is the first study involving 1.9 nm nanometre sized particles to report multiple cellular responses which impact on the radiation dose modifying effect, and highlights the need for extensive characterization of responses to gold nanoparticles when assessing dose enhancing potential in cancer therapy.
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Nanodosimetric effects of gold nanoparticles in megavoltage radiation therapy.
Stephen J. McMahon,Wendy B. Hyland,Mark F. Muir,Jonathan A. Coulter,Suneil Jain,Karl T. Butterworth,Giuseppe Schettino,Glenn R. Dickson,Alan R. Hounsell,Alan R. Hounsell,Joe M. O'Sullivan,Joe M. O'Sullivan,Kevin M. Prise,David G. Hirst,Frederick Currell +14 more
TL;DR: It is suggested that GNP radiosensitisation is driven by inhomogeneities in dose on the nanoscale, rather than changes in dose over the entire cell, which may contribute to the similar radiosensItisation observed in megavoltage and kilovoltage experiments.
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A charged-particle microbeam: I. Development of an experimental system for targeting cells individually with counted particles
Melvyn Folkard,Borivoj Vojnovic,Kevin M. Prise,A.G. Bowey,R J Locke,Giuseppe Schettino,B.D. Michael +6 more
TL;DR: The Gray Laboratory is now routinely operating a charged-particle microbeam capable of delivering targeted and counted particles to individual cells, at a dose-rate sufficient to permit a number of single-cell assays of radiation damage to be implemented.