C
Cecília M. P. Rodrigues
Researcher at University of Lisbon
Publications - 297
Citations - 27185
Cecília M. P. Rodrigues is an academic researcher from University of Lisbon. The author has contributed to research in topics: Apoptosis & Tauroursodeoxycholic acid. The author has an hindex of 63, co-authored 271 publications receiving 21706 citations. Previous affiliations of Cecília M. P. Rodrigues include Boston Children's Hospital & University of Minnesota.
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Journal ArticleDOI
Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease.
D.M.S. Ferreira,Rui E. Castro,Mariana V. Machado,T. Evangelista,Ana Rita Silvestre,Adília Costa,J. Coutinho,F. Carepa,Helena Cortez-Pinto,Cecília M. P. Rodrigues +9 more
TL;DR: The results demonstrate a link between apoptosis, insulin resistance and different NAFLD stages, where JNK and caspase-2 may play a key regulatory role.
Journal Article
Tool from ancient pharmacopoeia prevents vision loss
Jeffrey H Boatright,Anisha G. Moring,Clinton McElroy,M.J. Phillips,V.T. Do,Bo Chang,Norm L. Hawes,Amber P. Boyd,S. S. Sidney,R. E. Stewart,Steven C. Minear,Rajashree Chaudhury,Vincent T. Ciavatta,Cecília M. P. Rodrigues,Clifford J. Steer,John M. Nickerson,Machelle T. Pardue +16 more
TL;DR: Test whether treatment of mice undergoing retinal degeneration with tauroursodeoxycholic acid (TUDCA), a primary constituent of bear bile, alters the course of degeneration and results indicate that a systematic, clinical assessment of TUDCA may be warranted.
Journal ArticleDOI
Tauroursodeoxycholic acid (TUDCA) supplementation prevents cognitive impairment and amyloid deposition in APP/PS1 mice
TL;DR: Six months of TUDCA supplementation prevented the spatial, recognition and contextual memory defects observed in APP/PS1 mice at 8 months of age and suggest a novel mechanistic route for Alzheimer therapeutics.
Journal ArticleDOI
Relevance of serum bile acid profile in the diagnosis of intrahepatic cholestasis of pregnancy in an high incidence area: Portugal
TL;DR: Among routine liver tests, alanine aminotransferase and conjugated bilirubin were the most common indicators of ICP, and the most predictive and accurate markers were TBA concentration in serum and glycocholic acid concentration.
Journal ArticleDOI
Amyloid β-Peptide Disrupts Mitochondrial Membrane Lipid and Protein Structure: Protective Role of Tauroursodeoxycholate ☆
Cecília M. P. Rodrigues,Susana Solá,Maria Alexandra Brito,Carlos D. Brondino,Dora Brites,José J. G. Moura +5 more
TL;DR: It is concluded that A beta directly induces cytochrome c release from mitochondria through a mechanism that is accompanied by profound effects on mitochondrial membrane redox status, lipid polarity, and protein order, suggesting a neuroprotective role for this bile salt.