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Cecília M. P. Rodrigues
Researcher at University of Lisbon
Publications - 297
Citations - 27185
Cecília M. P. Rodrigues is an academic researcher from University of Lisbon. The author has contributed to research in topics: Apoptosis & Tauroursodeoxycholic acid. The author has an hindex of 63, co-authored 271 publications receiving 21706 citations. Previous affiliations of Cecília M. P. Rodrigues include Boston Children's Hospital & University of Minnesota.
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Journal ArticleDOI
Cobalt complexes bearing scorpionate ligands: synthesis, characterization, cytotoxicity and DNA cleavage
Telma F. S. Silva,Luísa M. D. R. S. Martins,M. Fátima C. Guedes da Silva,M. Fátima C. Guedes da Silva,Alexandra R. Fernandes,Alexandra R. Fernandes,Alexandra R. Fernandes,Ana Lorga da Silva,Pedro M. Borralho,Susana Santos,Susana Santos,Cecília M. P. Rodrigues,Armando J. L. Pombeiro +12 more
TL;DR: A number of novel, water-stable redox-active cobalt complexes of the C-functionalized tripodal ligands tris(pyrazolyl)methane XC(pz)(3) (X = HOCH(2), CH(2)OCH( 2)Py or CH(1)OSO (2)Me) are reported along with their effects on DNA.
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Cyclopentadienyl–Ruthenium(II) and Iron(II) Organometallic Compounds with Carbohydrate Derivative Ligands as Good Colorectal Anticancer Agents
Pedro Florindo,Diane M. Pereira,Pedro M. Borralho,Cecília M. P. Rodrigues,M. F. M. Piedade,M. F. M. Piedade,Ana C. Fernandes +6 more
TL;DR: Two compounds, 14Ru and 18Ru, matched oxaliplatin IC50, the standard metallodrug used in CC chemotherapeutics, and the leading compound 14Ru was shown to be significantly more cytotoxic than oxali Platin to HCT116 cells, triggering higher levels of caspase-3 and -7 activity and apoptosis in a dose-dependent manner.
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Amyloid-β pathology is attenuated by tauroursodeoxycholic acid treatment in APP/PS1 mice after disease onset
Pedro A. Dionísio,Joana D. Amaral,Maria F. Ribeiro,Adrian C. Lo,Rudi D'Hooge,Cecília M. P. Rodrigues +5 more
TL;DR: TUDCA treatment significantly attenuated Aβ deposition in the brain, with a concomitant decrease in Aβ₁₋₄₂ levels, and decreased glial activation and reduced proinflammatory cytokine messenger RNA expression, while partially rescuing synaptic loss.
Journal ArticleDOI
Tauroursodeoxycholic acid protects retinal neural cells from cell death induced by prolonged exposure to elevated glucose.
Joana M. Gaspar,António A. Martins,R. Cruz,Cecília M. P. Rodrigues,António F. Ambrósio,Ana Raquel Santiago +5 more
TL;DR: TUDCA protected retinal neural cell cultures from cell death induced by elevated glucose concentration, decreasing mito-nuclear translocation of AIF, and the antioxidant properties of TUDCA might explain its cytoprotection.
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KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2- c ]quinolines
João Lavrado,Hugo Brito,Pedro M. Borralho,Stephan A. Ohnmacht,Nam-Soon Kim,Clara Leitão,Sílvia Pisco,Mekala Gunaratnam,Cecília M. P. Rodrigues,Rui Moreira,Stephen Neidle,Alexandra Paulo +11 more
TL;DR: The results suggest that targeting mutant KRAS at the gene level with G4 binding small molecules is a promising anticancer strategy.